Diet and ethanol modulate immune responses in young C57BL/6 mice

B. Watzl, M. Lopez, M. Shahbazian, G. Chen, L. L. Colombo, D. Huang, D. Way, Ronald R Watson

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Chronic ethanol (ETOH) ingestion adversely affects the immunocompetence of alcohol abusers. ETOH directly impairs host defense mechanisms and indirectly modulates immunocompetence by interfering with the nutritional status of the alcoholic. It is not clear from the current literature, however, to what extent ETOH, nutritional status, or the combination of the two factors modulates immune mechanisms in chronic alcoholics. To date, most animal studies investigating the immunotoxicity of ETOH have neglected the dietary factors, which may have masked additional immunotoxic effects of ETOH. To examine these dietary factors, we fed mice three liquid ETOH diets with different dietary sufficiencies for 7 weeks and investigated various immune responses. Spleen cell number and secretions of immunoreactive interleukin-2 and tumor necrosis factor were totally independent of the diet, being affected only by ETOH. Body, spleen, and thymus weights, interferon-γ secretion, and natural killer cell and phagocytic activities were modulated by ETOH as well as by diet. Natural killer cell and phagocytic activities were also directly affected by the nutritional quality of the diet. These results suggest that animal diets used in experimental studies of ETOH- induced immunomodulation must be planned and controlled carefully in order to single out the direct effects that ETOH has on the host defense system.

Original languageEnglish (US)
Pages (from-to)623-630
Number of pages8
JournalAlcoholism: Clinical and Experimental Research
Volume17
Issue number3
StatePublished - 1993

Fingerprint

Nutrition
Inbred C57BL Mouse
Ethanol
Diet
Immunocompetence
Nutritional Status
Natural Killer Cells
Animals
Spleen
Thymus
Immunomodulation
Nutritive Value
Immunologic Factors
Alcoholics
Thymus Gland
Interferons
Interleukin-2
Tumor Necrosis Factor-alpha
Cell Count
Eating

Keywords

  • Animal Diets
  • Ethanol
  • Immunocompetence
  • Mice
  • Nutritional Status

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Watzl, B., Lopez, M., Shahbazian, M., Chen, G., Colombo, L. L., Huang, D., ... Watson, R. R. (1993). Diet and ethanol modulate immune responses in young C57BL/6 mice. Alcoholism: Clinical and Experimental Research, 17(3), 623-630.

Diet and ethanol modulate immune responses in young C57BL/6 mice. / Watzl, B.; Lopez, M.; Shahbazian, M.; Chen, G.; Colombo, L. L.; Huang, D.; Way, D.; Watson, Ronald R.

In: Alcoholism: Clinical and Experimental Research, Vol. 17, No. 3, 1993, p. 623-630.

Research output: Contribution to journalArticle

Watzl, B, Lopez, M, Shahbazian, M, Chen, G, Colombo, LL, Huang, D, Way, D & Watson, RR 1993, 'Diet and ethanol modulate immune responses in young C57BL/6 mice', Alcoholism: Clinical and Experimental Research, vol. 17, no. 3, pp. 623-630.
Watzl B, Lopez M, Shahbazian M, Chen G, Colombo LL, Huang D et al. Diet and ethanol modulate immune responses in young C57BL/6 mice. Alcoholism: Clinical and Experimental Research. 1993;17(3):623-630.
Watzl, B. ; Lopez, M. ; Shahbazian, M. ; Chen, G. ; Colombo, L. L. ; Huang, D. ; Way, D. ; Watson, Ronald R. / Diet and ethanol modulate immune responses in young C57BL/6 mice. In: Alcoholism: Clinical and Experimental Research. 1993 ; Vol. 17, No. 3. pp. 623-630.
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