Diet and health risk

Risk patterns and disease-specific associations

James R. Marshall, Zhao Chen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Whether such epidemiologic descriptors as relative risk, dose response, and threshold points convey meaningful information is often the subject of debate. Thus, using these descriptors to juxtapose the many disease-specific effects of nutritional exposures becomes problematic. In this article it is argued that epidemiologic patterns of disease-exposure associations must be interpreted in light of the profound imprecision of exposure assessment that characterizes nutritional epidemiology. In general, this imprecision leads to substantial attenuation of disease-exposure associations, such that relative risk, dose response, and the extent to which there are thresholds in disease- exposure associations can be seriously underestimated. Linking disease- specific relative risks, especially when derived from different studies with different methods of assessing exposure, is made increasingly difficult. The most critical tasks for lessening bias in these epidemiologic descriptors are first, to lessen imprecision in measuring exposures, and second, to adjust association estimates for attenuation due to measurement imprecision.

Original languageEnglish (US)
JournalAmerican Journal of Clinical Nutrition
Volume69
Issue number6
StatePublished - Jun 1999

Fingerprint

relative risk
Diet
dose response
Health
diet
exposure assessment
epidemiology
Nutrition Assessment
Epidemiology
methodology

Keywords

  • Attributable risk
  • Disease
  • Epidemiology
  • Exposure
  • Measurement error
  • Relative risk
  • Reliability
  • Validity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Diet and health risk : Risk patterns and disease-specific associations. / Marshall, James R.; Chen, Zhao.

In: American Journal of Clinical Nutrition, Vol. 69, No. 6, 06.1999.

Research output: Contribution to journalArticle

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