Diet and Nutrient Intakes and Risk of Non-Hodgkin's Lymphoma in Connecticut Women

Tongzhang Zheng, Theodore R. Holford, Brian Leaderer, Yawei Zhang, Shelia Hoar Zahm, Stuart D Flynn, Giovanni Tallini, Bing Zhang, Kaiyong Zhou, Patricia H. Owens, Qing Lan, Nathaniel Rothman, Peter Boyle

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

A population-based case-control study (601 cases and 717 controls) was conducted in 1995-2001 among Connecticut women to evaluate the relation between diet and nutrient intakes and the risk of non-Hodgkin's lymphoma (NHL). When the highest quartile of intake was compared with the lowest, the authors found an increased risk of NHL associated with animal protein (odds ratio = 1.7, 95% confidence interval: 1.2, 2.4) and saturated fat (odds ratio = 1.9, 95% confidence interval: 1.11, 2.3) but a reduced risk for polyunsaturated fat (odds ratio = 0.6, 95% confidence interval: 0.4, 0.9) and no relation for vegetable protein and monounsaturated fat. An increased risk was also observed for higher intakes of retinol, eggs, and dairy products. On the other hand, a reduced risk was found for higher intakes of dietary fiber and for several fruit and vegetable items. Risk of NHL associated with diet and nutrient intakes appeared to vary based on NHL subtype. An association between dietary intake and NHL risk is biologically plausible because diets high in protein and fat may lead to altered immunocompetence, resulting in an increased risk of NHL. The antioxidant or inhibiting nitrosation reaction properties of vegetables and fruits may result in a reduced risk. Further investigation of the role of dietary intakes on the risk of NHL is warranted.

Original languageEnglish (US)
Pages (from-to)454-466
Number of pages13
JournalAmerican Journal of Epidemiology
Volume159
Issue number5
DOIs
StatePublished - Mar 1 2004
Externally publishedYes

Fingerprint

Non-Hodgkin's Lymphoma
Diet
Food
Fats
Odds Ratio
Confidence Intervals
Vegetables
Fruit
Vegetable Proteins
Nitrosation
Immunocompetence
Dairy Products
Dietary Fiber
Vitamin A
Eggs
Case-Control Studies
Proteins
Antioxidants

Keywords

  • Case-control studies
  • Diet
  • Dietary fats
  • Lymphoma
  • Non-Hodgkin
  • Proteins
  • Risk factors
  • Women

ASJC Scopus subject areas

  • Epidemiology

Cite this

Zheng, T., Holford, T. R., Leaderer, B., Zhang, Y., Zahm, S. H., Flynn, S. D., ... Boyle, P. (2004). Diet and Nutrient Intakes and Risk of Non-Hodgkin's Lymphoma in Connecticut Women. American Journal of Epidemiology, 159(5), 454-466. https://doi.org/10.1093/aje/kwh067

Diet and Nutrient Intakes and Risk of Non-Hodgkin's Lymphoma in Connecticut Women. / Zheng, Tongzhang; Holford, Theodore R.; Leaderer, Brian; Zhang, Yawei; Zahm, Shelia Hoar; Flynn, Stuart D; Tallini, Giovanni; Zhang, Bing; Zhou, Kaiyong; Owens, Patricia H.; Lan, Qing; Rothman, Nathaniel; Boyle, Peter.

In: American Journal of Epidemiology, Vol. 159, No. 5, 01.03.2004, p. 454-466.

Research output: Contribution to journalArticle

Zheng, T, Holford, TR, Leaderer, B, Zhang, Y, Zahm, SH, Flynn, SD, Tallini, G, Zhang, B, Zhou, K, Owens, PH, Lan, Q, Rothman, N & Boyle, P 2004, 'Diet and Nutrient Intakes and Risk of Non-Hodgkin's Lymphoma in Connecticut Women', American Journal of Epidemiology, vol. 159, no. 5, pp. 454-466. https://doi.org/10.1093/aje/kwh067
Zheng, Tongzhang ; Holford, Theodore R. ; Leaderer, Brian ; Zhang, Yawei ; Zahm, Shelia Hoar ; Flynn, Stuart D ; Tallini, Giovanni ; Zhang, Bing ; Zhou, Kaiyong ; Owens, Patricia H. ; Lan, Qing ; Rothman, Nathaniel ; Boyle, Peter. / Diet and Nutrient Intakes and Risk of Non-Hodgkin's Lymphoma in Connecticut Women. In: American Journal of Epidemiology. 2004 ; Vol. 159, No. 5. pp. 454-466.
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