Dietary change and reduced breast cancer events among women without hot flashes after treatment of early-stage breast cancer

Subgroup analysis of the Women's Healthy Eating and Living Study

John P. Pierce, Loki Natarajan, Bette J. Caan, Shirley W. Flatt, Sheila Kealey, Ellen B. Gold, Richard A. Hajek, Vicky A. Newman, Cheryl L. Rock, Minya Pu, Nazmus Saquib, Marcia L. Stefanick, Cynthia Thomson, Barbara Parker

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background: A diet high in vegetables, fruit, and fiber and low in fat decreased additional risk of secondary breast cancer events in women without hot flashes (HF-) compared with that in women with hot flashes (HF+), possibly through lowered concentrations of circulating estrogens. Objective: The objective was to investigate the intervention effect by baseline quartiles of dietary pattern among breast cancer survivors in the HF- subgroup of the Women's Healthy Eating and Living Study. Design: A randomized controlled trial compared a putative cancer prevention diet with a diet of 5 servings of vegetables and fruit daily in early-stage breast cancer survivors. Participants did not experience hot flashes at baseline (n = 896). We confirmed cancer status for 96% of participants ≈7.3 y after enrollment. Results: The study intervention achieved a large between-group difference in dietary pattern that, at 4 y, was not significantly different across baseline quartiles of dietary pattern. The intervention group experienced fewer breast cancer events than did the comparison group for all of the baseline quartiles. This difference was significant only in upper baseline quartiles of intake of vegetables, fruit, and fiber and in the lowest quartile of fat. A significant trend for fewer breast cancer events was observed across quartiles of vegetable-fruit and fiber consumption. Conclusions: The secondary analysis showing the decreased risk in the HF- subgroup was not explained by amount of change in dietary pattern achieved. The difference was strongest in the quartile with the most putatively cancer-preventive dietary pattern at baseline.

Original languageEnglish (US)
JournalAmerican Journal of Clinical Nutrition
Volume89
Issue number5
DOIs
StatePublished - Jan 5 2009

Fingerprint

Hot Flashes
Vegetables
Breast Neoplasms
Fruit
Diet
Survivors
Fats
Therapeutics
Neoplasms
Estrogens
Randomized Controlled Trials
Healthy Diet

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Dietary change and reduced breast cancer events among women without hot flashes after treatment of early-stage breast cancer : Subgroup analysis of the Women's Healthy Eating and Living Study. / Pierce, John P.; Natarajan, Loki; Caan, Bette J.; Flatt, Shirley W.; Kealey, Sheila; Gold, Ellen B.; Hajek, Richard A.; Newman, Vicky A.; Rock, Cheryl L.; Pu, Minya; Saquib, Nazmus; Stefanick, Marcia L.; Thomson, Cynthia; Parker, Barbara.

In: American Journal of Clinical Nutrition, Vol. 89, No. 5, 05.01.2009.

Research output: Contribution to journalArticle

Pierce, John P. ; Natarajan, Loki ; Caan, Bette J. ; Flatt, Shirley W. ; Kealey, Sheila ; Gold, Ellen B. ; Hajek, Richard A. ; Newman, Vicky A. ; Rock, Cheryl L. ; Pu, Minya ; Saquib, Nazmus ; Stefanick, Marcia L. ; Thomson, Cynthia ; Parker, Barbara. / Dietary change and reduced breast cancer events among women without hot flashes after treatment of early-stage breast cancer : Subgroup analysis of the Women's Healthy Eating and Living Study. In: American Journal of Clinical Nutrition. 2009 ; Vol. 89, No. 5.
@article{3d8535e9dcb04611b7958f88134ef268,
title = "Dietary change and reduced breast cancer events among women without hot flashes after treatment of early-stage breast cancer: Subgroup analysis of the Women's Healthy Eating and Living Study",
abstract = "Background: A diet high in vegetables, fruit, and fiber and low in fat decreased additional risk of secondary breast cancer events in women without hot flashes (HF-) compared with that in women with hot flashes (HF+), possibly through lowered concentrations of circulating estrogens. Objective: The objective was to investigate the intervention effect by baseline quartiles of dietary pattern among breast cancer survivors in the HF- subgroup of the Women's Healthy Eating and Living Study. Design: A randomized controlled trial compared a putative cancer prevention diet with a diet of 5 servings of vegetables and fruit daily in early-stage breast cancer survivors. Participants did not experience hot flashes at baseline (n = 896). We confirmed cancer status for 96{\%} of participants ≈7.3 y after enrollment. Results: The study intervention achieved a large between-group difference in dietary pattern that, at 4 y, was not significantly different across baseline quartiles of dietary pattern. The intervention group experienced fewer breast cancer events than did the comparison group for all of the baseline quartiles. This difference was significant only in upper baseline quartiles of intake of vegetables, fruit, and fiber and in the lowest quartile of fat. A significant trend for fewer breast cancer events was observed across quartiles of vegetable-fruit and fiber consumption. Conclusions: The secondary analysis showing the decreased risk in the HF- subgroup was not explained by amount of change in dietary pattern achieved. The difference was strongest in the quartile with the most putatively cancer-preventive dietary pattern at baseline.",
author = "Pierce, {John P.} and Loki Natarajan and Caan, {Bette J.} and Flatt, {Shirley W.} and Sheila Kealey and Gold, {Ellen B.} and Hajek, {Richard A.} and Newman, {Vicky A.} and Rock, {Cheryl L.} and Minya Pu and Nazmus Saquib and Stefanick, {Marcia L.} and Cynthia Thomson and Barbara Parker",
year = "2009",
month = "1",
day = "5",
doi = "10.3945/ajcn.2009.26736F",
language = "English (US)",
volume = "89",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "5",

}

TY - JOUR

T1 - Dietary change and reduced breast cancer events among women without hot flashes after treatment of early-stage breast cancer

T2 - Subgroup analysis of the Women's Healthy Eating and Living Study

AU - Pierce, John P.

AU - Natarajan, Loki

AU - Caan, Bette J.

AU - Flatt, Shirley W.

AU - Kealey, Sheila

AU - Gold, Ellen B.

AU - Hajek, Richard A.

AU - Newman, Vicky A.

AU - Rock, Cheryl L.

AU - Pu, Minya

AU - Saquib, Nazmus

AU - Stefanick, Marcia L.

AU - Thomson, Cynthia

AU - Parker, Barbara

PY - 2009/1/5

Y1 - 2009/1/5

N2 - Background: A diet high in vegetables, fruit, and fiber and low in fat decreased additional risk of secondary breast cancer events in women without hot flashes (HF-) compared with that in women with hot flashes (HF+), possibly through lowered concentrations of circulating estrogens. Objective: The objective was to investigate the intervention effect by baseline quartiles of dietary pattern among breast cancer survivors in the HF- subgroup of the Women's Healthy Eating and Living Study. Design: A randomized controlled trial compared a putative cancer prevention diet with a diet of 5 servings of vegetables and fruit daily in early-stage breast cancer survivors. Participants did not experience hot flashes at baseline (n = 896). We confirmed cancer status for 96% of participants ≈7.3 y after enrollment. Results: The study intervention achieved a large between-group difference in dietary pattern that, at 4 y, was not significantly different across baseline quartiles of dietary pattern. The intervention group experienced fewer breast cancer events than did the comparison group for all of the baseline quartiles. This difference was significant only in upper baseline quartiles of intake of vegetables, fruit, and fiber and in the lowest quartile of fat. A significant trend for fewer breast cancer events was observed across quartiles of vegetable-fruit and fiber consumption. Conclusions: The secondary analysis showing the decreased risk in the HF- subgroup was not explained by amount of change in dietary pattern achieved. The difference was strongest in the quartile with the most putatively cancer-preventive dietary pattern at baseline.

AB - Background: A diet high in vegetables, fruit, and fiber and low in fat decreased additional risk of secondary breast cancer events in women without hot flashes (HF-) compared with that in women with hot flashes (HF+), possibly through lowered concentrations of circulating estrogens. Objective: The objective was to investigate the intervention effect by baseline quartiles of dietary pattern among breast cancer survivors in the HF- subgroup of the Women's Healthy Eating and Living Study. Design: A randomized controlled trial compared a putative cancer prevention diet with a diet of 5 servings of vegetables and fruit daily in early-stage breast cancer survivors. Participants did not experience hot flashes at baseline (n = 896). We confirmed cancer status for 96% of participants ≈7.3 y after enrollment. Results: The study intervention achieved a large between-group difference in dietary pattern that, at 4 y, was not significantly different across baseline quartiles of dietary pattern. The intervention group experienced fewer breast cancer events than did the comparison group for all of the baseline quartiles. This difference was significant only in upper baseline quartiles of intake of vegetables, fruit, and fiber and in the lowest quartile of fat. A significant trend for fewer breast cancer events was observed across quartiles of vegetable-fruit and fiber consumption. Conclusions: The secondary analysis showing the decreased risk in the HF- subgroup was not explained by amount of change in dietary pattern achieved. The difference was strongest in the quartile with the most putatively cancer-preventive dietary pattern at baseline.

UR - http://www.scopus.com/inward/record.url?scp=65549089621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65549089621&partnerID=8YFLogxK

U2 - 10.3945/ajcn.2009.26736F

DO - 10.3945/ajcn.2009.26736F

M3 - Article

VL - 89

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -