Dietary flavonoids improve urinary arsenic elimination among Mexican women

Grant Quiller, Ángel Mérida-Ortega, Stephen J. Rothenberg, Mariano E. Cebrián, A Jay Gandolfi, Francisco Franco-Marina, Lizbeth López-Carrillo

Research output: Contribution to journalArticle

Abstract

Inorganic arsenic (iAs) exposure increases risk of several diseases, including cancer. Some nutrients such as flavonoids enhance glutathione activity, which in turn play a key role in iAs elimination. Our objective was to explore whether dietary non-soy flavonoids are associated with iAs metabolism. We hypothesized that the intake of flavonoids belonging to the following groups, flavan-3-ols, flavone, flavonol, flavanone, and anthocyanidin, is positively associated with urinary dimethylarsinic acid (DMA), which is the most soluble iAs metabolite excreted. We performed a cross-sectional study that included 1027 women living in an arsenic-contaminated area of northern Mexico. Flavonoid intake was estimated using a validated food frequency questionnaire. Concentration of urinary iAs and its metabolites (monomethylarsonic acid and DMA) were determined by high performance liquid chromatography ICP-MS. Results showed positive significant associations between DMA and the flavonoid groups flava-3-ols (β= 0.0112) and flavones (β= 0.0144), as well as the individual intake of apigenin (β= 0.0115), luteolin (β= 0.0138), and eriodictyol (β= 0.0026). Our findings suggest that certain non-soy flavonoids may improve iAs elimination; however, there is still very limited information available regarding the consumption of flavonoids and iAs metabolism.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalNutrition Research
Volume55
DOIs
StatePublished - Jul 1 2018

Fingerprint

Arsenic
Flavonoids
Cacodylic Acid
flavone
Flavones
Apigenin
Luteolin
Food
Anthocyanins
Mexico
Glutathione
Cross-Sectional Studies
High Pressure Liquid Chromatography

Keywords

  • Arsenic metabolism
  • Cross-sectional study
  • Flavonoids
  • Mexico

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Quiller, G., Mérida-Ortega, Á., Rothenberg, S. J., Cebrián, M. E., Gandolfi, A. J., Franco-Marina, F., & López-Carrillo, L. (2018). Dietary flavonoids improve urinary arsenic elimination among Mexican women. Nutrition Research, 55, 65-71. https://doi.org/10.1016/j.nutres.2018.04.012

Dietary flavonoids improve urinary arsenic elimination among Mexican women. / Quiller, Grant; Mérida-Ortega, Ángel; Rothenberg, Stephen J.; Cebrián, Mariano E.; Gandolfi, A Jay; Franco-Marina, Francisco; López-Carrillo, Lizbeth.

In: Nutrition Research, Vol. 55, 01.07.2018, p. 65-71.

Research output: Contribution to journalArticle

Quiller, G, Mérida-Ortega, Á, Rothenberg, SJ, Cebrián, ME, Gandolfi, AJ, Franco-Marina, F & López-Carrillo, L 2018, 'Dietary flavonoids improve urinary arsenic elimination among Mexican women', Nutrition Research, vol. 55, pp. 65-71. https://doi.org/10.1016/j.nutres.2018.04.012
Quiller G, Mérida-Ortega Á, Rothenberg SJ, Cebrián ME, Gandolfi AJ, Franco-Marina F et al. Dietary flavonoids improve urinary arsenic elimination among Mexican women. Nutrition Research. 2018 Jul 1;55:65-71. https://doi.org/10.1016/j.nutres.2018.04.012
Quiller, Grant ; Mérida-Ortega, Ángel ; Rothenberg, Stephen J. ; Cebrián, Mariano E. ; Gandolfi, A Jay ; Franco-Marina, Francisco ; López-Carrillo, Lizbeth. / Dietary flavonoids improve urinary arsenic elimination among Mexican women. In: Nutrition Research. 2018 ; Vol. 55. pp. 65-71.
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