Dietary Intake and Risk of Persistent Human Papillomavirus (HPV) Infection: The Ludwig-McGill HPV Natural History Study

Anna R. Giuliano, Erin M. Siegel, Denise J. Roe, Silvandeiede Ferreira, Maria Luiza Baggio, Lenice Galan, Eliane Duarte-Franco, Luisa L. Villa, Thomas E. Rohan, James R. Marshall, Eduardo L. Franco

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

The association between dietary intake and persistence of type-specific human papillomavirus (HPV) infection, during a 12-month period, among 433 women participating in the Ludwig-McGill HPV Natural History Study was evaluated by use of a nested case-control design. Dietary intake was assessed by a food-frequency questionnaire at the month-4 visit. HPV status was assessed at months 0, 4, 8, and 12 by polymerase chain reaction (MY09/11). Only women who ever tested positive for HPV were included in the present study: 248 had transient HPV infections (1 of 4 positive tests or nonconsecutively positive), and 185 had persistent HPV infections (≥2 consecutive tests positive for the same HPV type). Risk of type-specific, persistent HPV infection was lower among women reporting intake values of β-cryptoxanthin and lutein/zeaxanthin in the upper 2 quartiles and intake values of vitamin C in the upper quartile, compared with those reporting intake in the lowest quartile. Consumption of papaya ≥1 time/week was inversely associated with persistent HPV infection.

Original languageEnglish (US)
Pages (from-to)1508-1516
Number of pages9
JournalJournal of Infectious Diseases
Volume188
Issue number10
DOIs
StatePublished - Nov 15 2003

    Fingerprint

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Giuliano, A. R., Siegel, E. M., Roe, D. J., Ferreira, S., Baggio, M. L., Galan, L., Duarte-Franco, E., Villa, L. L., Rohan, T. E., Marshall, J. R., & Franco, E. L. (2003). Dietary Intake and Risk of Persistent Human Papillomavirus (HPV) Infection: The Ludwig-McGill HPV Natural History Study. Journal of Infectious Diseases, 188(10), 1508-1516. https://doi.org/10.1086/379197