Dietary iron positively influences bone mineral density in postmenopausal women on hormone replacement therapy

Jaclyn Maurer, Margaret M. Harris, Vanessa A. Stanford, Timothy G Lohman, Ellen Cussler, Scott B Going, Linda K Houtkooper

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The associations of dietary intakes of iron and calcium on change in bone mineral density (BMD) were examined over 1 y in healthy nonsmoking postmenopausal women (mean age 55.6 ± 4.6 y) stratified by hormone replacement therapy (HRT) use (HRT, n = 116; no HRT, n = 112). BMD was measured at lumbar spine L2-L4, trochanter, femur neck, Ward's triangle, and total body using dual-energy X-ray absorptiometry at baseline and 1 y. Mean nutrient intakes were assessed using 8-d diet records. All women received 800 mg/d of supplemental elemental calcium. Regression analyses examined the effects of iron and calcium intakes on BMD change adjusting for years past menopause, baseline BMD, weight change, exercise, and energy intake. The interaction of iron with calcium on BMD change was assessed using tertiles of iron and calcium intake and estimated marginal mean change in BMD. Iron was associated (P < 0.05) with greater positive BMD change at the trochanter and Ward's triangle in women using HRT. Calcium was associated (P < 0.05) with BMD change at the trochanter and femur neck for women not using HRT. In women using HRT in the lowest tertile of calcium intake, change in femur neck BMD increased linearly as iron intake increased. In women not using HRT, BMD increased in the women in the highest tertile of calcium intake. We conclude that HRT use appears to influence the associations of iron and calcium on change in BMD.

Original languageEnglish (US)
Pages (from-to)863-869
Number of pages7
JournalJournal of Nutrition
Volume135
Issue number4
StatePublished - Apr 2005

Fingerprint

hormone replacement therapy
Dietary Iron
Hormone Replacement Therapy
bone density
Bone Density
iron
calcium
Calcium
Iron
Femur Neck
femur
Femur
neck
lumbar spine
Diet Records
Dietary Calcium
menopause
dual-energy X-ray absorptiometry
Photon Absorptiometry
Menopause

Keywords

  • Bone mineral density
  • Hormone replacement therapy
  • Iron
  • Postmenopausal

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Dietary iron positively influences bone mineral density in postmenopausal women on hormone replacement therapy. / Maurer, Jaclyn; Harris, Margaret M.; Stanford, Vanessa A.; Lohman, Timothy G; Cussler, Ellen; Going, Scott B; Houtkooper, Linda K.

In: Journal of Nutrition, Vol. 135, No. 4, 04.2005, p. 863-869.

Research output: Contribution to journalArticle

@article{90b3640673be45a19c93207010e60916,
title = "Dietary iron positively influences bone mineral density in postmenopausal women on hormone replacement therapy",
abstract = "The associations of dietary intakes of iron and calcium on change in bone mineral density (BMD) were examined over 1 y in healthy nonsmoking postmenopausal women (mean age 55.6 ± 4.6 y) stratified by hormone replacement therapy (HRT) use (HRT, n = 116; no HRT, n = 112). BMD was measured at lumbar spine L2-L4, trochanter, femur neck, Ward's triangle, and total body using dual-energy X-ray absorptiometry at baseline and 1 y. Mean nutrient intakes were assessed using 8-d diet records. All women received 800 mg/d of supplemental elemental calcium. Regression analyses examined the effects of iron and calcium intakes on BMD change adjusting for years past menopause, baseline BMD, weight change, exercise, and energy intake. The interaction of iron with calcium on BMD change was assessed using tertiles of iron and calcium intake and estimated marginal mean change in BMD. Iron was associated (P < 0.05) with greater positive BMD change at the trochanter and Ward's triangle in women using HRT. Calcium was associated (P < 0.05) with BMD change at the trochanter and femur neck for women not using HRT. In women using HRT in the lowest tertile of calcium intake, change in femur neck BMD increased linearly as iron intake increased. In women not using HRT, BMD increased in the women in the highest tertile of calcium intake. We conclude that HRT use appears to influence the associations of iron and calcium on change in BMD.",
keywords = "Bone mineral density, Hormone replacement therapy, Iron, Postmenopausal",
author = "Jaclyn Maurer and Harris, {Margaret M.} and Stanford, {Vanessa A.} and Lohman, {Timothy G} and Ellen Cussler and Going, {Scott B} and Houtkooper, {Linda K}",
year = "2005",
month = "4",
language = "English (US)",
volume = "135",
pages = "863--869",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "4",

}

TY - JOUR

T1 - Dietary iron positively influences bone mineral density in postmenopausal women on hormone replacement therapy

AU - Maurer, Jaclyn

AU - Harris, Margaret M.

AU - Stanford, Vanessa A.

AU - Lohman, Timothy G

AU - Cussler, Ellen

AU - Going, Scott B

AU - Houtkooper, Linda K

PY - 2005/4

Y1 - 2005/4

N2 - The associations of dietary intakes of iron and calcium on change in bone mineral density (BMD) were examined over 1 y in healthy nonsmoking postmenopausal women (mean age 55.6 ± 4.6 y) stratified by hormone replacement therapy (HRT) use (HRT, n = 116; no HRT, n = 112). BMD was measured at lumbar spine L2-L4, trochanter, femur neck, Ward's triangle, and total body using dual-energy X-ray absorptiometry at baseline and 1 y. Mean nutrient intakes were assessed using 8-d diet records. All women received 800 mg/d of supplemental elemental calcium. Regression analyses examined the effects of iron and calcium intakes on BMD change adjusting for years past menopause, baseline BMD, weight change, exercise, and energy intake. The interaction of iron with calcium on BMD change was assessed using tertiles of iron and calcium intake and estimated marginal mean change in BMD. Iron was associated (P < 0.05) with greater positive BMD change at the trochanter and Ward's triangle in women using HRT. Calcium was associated (P < 0.05) with BMD change at the trochanter and femur neck for women not using HRT. In women using HRT in the lowest tertile of calcium intake, change in femur neck BMD increased linearly as iron intake increased. In women not using HRT, BMD increased in the women in the highest tertile of calcium intake. We conclude that HRT use appears to influence the associations of iron and calcium on change in BMD.

AB - The associations of dietary intakes of iron and calcium on change in bone mineral density (BMD) were examined over 1 y in healthy nonsmoking postmenopausal women (mean age 55.6 ± 4.6 y) stratified by hormone replacement therapy (HRT) use (HRT, n = 116; no HRT, n = 112). BMD was measured at lumbar spine L2-L4, trochanter, femur neck, Ward's triangle, and total body using dual-energy X-ray absorptiometry at baseline and 1 y. Mean nutrient intakes were assessed using 8-d diet records. All women received 800 mg/d of supplemental elemental calcium. Regression analyses examined the effects of iron and calcium intakes on BMD change adjusting for years past menopause, baseline BMD, weight change, exercise, and energy intake. The interaction of iron with calcium on BMD change was assessed using tertiles of iron and calcium intake and estimated marginal mean change in BMD. Iron was associated (P < 0.05) with greater positive BMD change at the trochanter and Ward's triangle in women using HRT. Calcium was associated (P < 0.05) with BMD change at the trochanter and femur neck for women not using HRT. In women using HRT in the lowest tertile of calcium intake, change in femur neck BMD increased linearly as iron intake increased. In women not using HRT, BMD increased in the women in the highest tertile of calcium intake. We conclude that HRT use appears to influence the associations of iron and calcium on change in BMD.

KW - Bone mineral density

KW - Hormone replacement therapy

KW - Iron

KW - Postmenopausal

UR - http://www.scopus.com/inward/record.url?scp=16244399832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16244399832&partnerID=8YFLogxK

M3 - Article

VL - 135

SP - 863

EP - 869

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 4

ER -