Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women

Lizbeth López-Carrillo, Brenda Gamboa-Loira, Wendy Becerra, César Hernández-Alcaraz, Raúl Ulises Hernández-Ramírez, A Jay Gandolfi, Francisco Franco-Marina, Mariano E. Cebrián

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Introduction Concentrations of inorganic arsenic (iAs) metabolites in urine present intra- and interindividual variations, which are determined not only by the magnitude of exposure to iAs, but also by differences in genetic, environmental and dietary factors. Objective To evaluate whether differences in dietary intake of selected micronutrients are associated with the metabolism of iAs. Methods The intake of 21 micronutrients was estimated for 1027 women living in northern Mexico using a food frequency questionnaire. Concentration of urinary metabolites of iAs was determined by high performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) and the proportion of iAs metabolites was calculated (%iAs, monomethylarsonic acid [%MMA] and dimethylarsinic acid [%DMA]), as well as ratios corresponding to the first (MMA/iAs), second (DMA/MMA) and total methylation (DMA/iAs). Results After adjustment for covariates, it was found that methionine, choline, folate, vitamin B12, Zn, Se and vitamin C favor elimination of iAs mainly by decreasing the %MMA and/or increasing %DMA in urine. Conclusions Our results confirm that diet contributes to the efficiency of iAs elimination. Further studies are needed to assess the feasibility of dietary interventions that modulate the metabolism of iAs and the consequent risk of diseases related to its exposure.

Original languageEnglish (US)
Pages (from-to)445-450
Number of pages6
JournalEnvironmental Research
Volume151
DOIs
StatePublished - Nov 1 2016

Fingerprint

Micronutrients
Arsenic
Metabolism
arsenic
metabolism
trace element
Dynamic mechanical analysis
Metabolites
metabolite
urine
woman
Urine
Cacodylic Acid
Inductively coupled plasma mass spectrometry
Methylation
Vitamin B 12
acid
Choline
Mexico
methylation

Keywords

  • Arsenic metabolism
  • Inorganic arsenic
  • Micronutrients
  • Northern Mexico

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Environmental Science(all)

Cite this

López-Carrillo, L., Gamboa-Loira, B., Becerra, W., Hernández-Alcaraz, C., Hernández-Ramírez, R. U., Gandolfi, A. J., ... Cebrián, M. E. (2016). Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women. Environmental Research, 151, 445-450. https://doi.org/10.1016/j.envres.2016.08.015

Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women. / López-Carrillo, Lizbeth; Gamboa-Loira, Brenda; Becerra, Wendy; Hernández-Alcaraz, César; Hernández-Ramírez, Raúl Ulises; Gandolfi, A Jay; Franco-Marina, Francisco; Cebrián, Mariano E.

In: Environmental Research, Vol. 151, 01.11.2016, p. 445-450.

Research output: Contribution to journalArticle

López-Carrillo, L, Gamboa-Loira, B, Becerra, W, Hernández-Alcaraz, C, Hernández-Ramírez, RU, Gandolfi, AJ, Franco-Marina, F & Cebrián, ME 2016, 'Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women', Environmental Research, vol. 151, pp. 445-450. https://doi.org/10.1016/j.envres.2016.08.015
López-Carrillo L, Gamboa-Loira B, Becerra W, Hernández-Alcaraz C, Hernández-Ramírez RU, Gandolfi AJ et al. Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women. Environmental Research. 2016 Nov 1;151:445-450. https://doi.org/10.1016/j.envres.2016.08.015
López-Carrillo, Lizbeth ; Gamboa-Loira, Brenda ; Becerra, Wendy ; Hernández-Alcaraz, César ; Hernández-Ramírez, Raúl Ulises ; Gandolfi, A Jay ; Franco-Marina, Francisco ; Cebrián, Mariano E. / Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women. In: Environmental Research. 2016 ; Vol. 151. pp. 445-450.
@article{50bc3f4798634a7fb6b264408b6cc127,
title = "Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women",
abstract = "Introduction Concentrations of inorganic arsenic (iAs) metabolites in urine present intra- and interindividual variations, which are determined not only by the magnitude of exposure to iAs, but also by differences in genetic, environmental and dietary factors. Objective To evaluate whether differences in dietary intake of selected micronutrients are associated with the metabolism of iAs. Methods The intake of 21 micronutrients was estimated for 1027 women living in northern Mexico using a food frequency questionnaire. Concentration of urinary metabolites of iAs was determined by high performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) and the proportion of iAs metabolites was calculated ({\%}iAs, monomethylarsonic acid [{\%}MMA] and dimethylarsinic acid [{\%}DMA]), as well as ratios corresponding to the first (MMA/iAs), second (DMA/MMA) and total methylation (DMA/iAs). Results After adjustment for covariates, it was found that methionine, choline, folate, vitamin B12, Zn, Se and vitamin C favor elimination of iAs mainly by decreasing the {\%}MMA and/or increasing {\%}DMA in urine. Conclusions Our results confirm that diet contributes to the efficiency of iAs elimination. Further studies are needed to assess the feasibility of dietary interventions that modulate the metabolism of iAs and the consequent risk of diseases related to its exposure.",
keywords = "Arsenic metabolism, Inorganic arsenic, Micronutrients, Northern Mexico",
author = "Lizbeth L{\'o}pez-Carrillo and Brenda Gamboa-Loira and Wendy Becerra and C{\'e}sar Hern{\'a}ndez-Alcaraz and Hern{\'a}ndez-Ram{\'i}rez, {Ra{\'u}l Ulises} and Gandolfi, {A Jay} and Francisco Franco-Marina and Cebri{\'a}n, {Mariano E.}",
year = "2016",
month = "11",
day = "1",
doi = "10.1016/j.envres.2016.08.015",
language = "English (US)",
volume = "151",
pages = "445--450",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women

AU - López-Carrillo, Lizbeth

AU - Gamboa-Loira, Brenda

AU - Becerra, Wendy

AU - Hernández-Alcaraz, César

AU - Hernández-Ramírez, Raúl Ulises

AU - Gandolfi, A Jay

AU - Franco-Marina, Francisco

AU - Cebrián, Mariano E.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Introduction Concentrations of inorganic arsenic (iAs) metabolites in urine present intra- and interindividual variations, which are determined not only by the magnitude of exposure to iAs, but also by differences in genetic, environmental and dietary factors. Objective To evaluate whether differences in dietary intake of selected micronutrients are associated with the metabolism of iAs. Methods The intake of 21 micronutrients was estimated for 1027 women living in northern Mexico using a food frequency questionnaire. Concentration of urinary metabolites of iAs was determined by high performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) and the proportion of iAs metabolites was calculated (%iAs, monomethylarsonic acid [%MMA] and dimethylarsinic acid [%DMA]), as well as ratios corresponding to the first (MMA/iAs), second (DMA/MMA) and total methylation (DMA/iAs). Results After adjustment for covariates, it was found that methionine, choline, folate, vitamin B12, Zn, Se and vitamin C favor elimination of iAs mainly by decreasing the %MMA and/or increasing %DMA in urine. Conclusions Our results confirm that diet contributes to the efficiency of iAs elimination. Further studies are needed to assess the feasibility of dietary interventions that modulate the metabolism of iAs and the consequent risk of diseases related to its exposure.

AB - Introduction Concentrations of inorganic arsenic (iAs) metabolites in urine present intra- and interindividual variations, which are determined not only by the magnitude of exposure to iAs, but also by differences in genetic, environmental and dietary factors. Objective To evaluate whether differences in dietary intake of selected micronutrients are associated with the metabolism of iAs. Methods The intake of 21 micronutrients was estimated for 1027 women living in northern Mexico using a food frequency questionnaire. Concentration of urinary metabolites of iAs was determined by high performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) and the proportion of iAs metabolites was calculated (%iAs, monomethylarsonic acid [%MMA] and dimethylarsinic acid [%DMA]), as well as ratios corresponding to the first (MMA/iAs), second (DMA/MMA) and total methylation (DMA/iAs). Results After adjustment for covariates, it was found that methionine, choline, folate, vitamin B12, Zn, Se and vitamin C favor elimination of iAs mainly by decreasing the %MMA and/or increasing %DMA in urine. Conclusions Our results confirm that diet contributes to the efficiency of iAs elimination. Further studies are needed to assess the feasibility of dietary interventions that modulate the metabolism of iAs and the consequent risk of diseases related to its exposure.

KW - Arsenic metabolism

KW - Inorganic arsenic

KW - Micronutrients

KW - Northern Mexico

UR - http://www.scopus.com/inward/record.url?scp=84983465450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983465450&partnerID=8YFLogxK

U2 - 10.1016/j.envres.2016.08.015

DO - 10.1016/j.envres.2016.08.015

M3 - Article

C2 - 27565879

AN - SCOPUS:84983465450

VL - 151

SP - 445

EP - 450

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -