Dietary modification with dairy products for preventing vertebral bone loss in premenopausal women: A three-year prospective study

Daniel Baran, Ann Sorensen, Joyce Grimes, Robert Lew, Andrew Karellas, Brian Johnson, Jane Roche

Research output: Contribution to journalArticle

168 Scopus citations

Abstract

The effect of dietary calcium on vertebral bone mass in women is controversial. In a randomized study we have investigated the effect of dietary modification in the form of dairy products on vertebral bone mass in 30- to 42-yr-old premenopausal women over a 3-yr period. Twenty women increased their dietary calcium intake by an average of 610 mg/day (P < 0.03) for 3 yr, while 17 age- and weight-matched women served as controls. Calcium intake was monitored by 3-day diet histories and 24-h urinary calcium excretion. The consumption of the dairy products did not alter serum calcium or PTH levels or the fasting urinary calcium to creatinine ratio. Twenty-four-hour urinary calcium excretion increased by 28% (P < 0.03) in the supplemented women. Dairy product intake was accompanied by increased dietary fat intake, but there were no statistically significant changes in serum cholesterol, low density lipoprotein cholesterol, or high density lipoprotein cholesterol levels. The vertebral bone density in the women consuming increased calcium did not change over the 3-yr period (−0.4 ± 0.9%). In contrast, the vertebral bone density in the control women declined (−2.9 ± 0.8%; P < 0.001) and was significantly lower than that in the supplemented group at 30 and 36 months. The study suggests that dietary modification in the form of dairy products retards vertebral bone loss in premenopausal women. Therefore, increased calcium intake in estrogen-replete premenopausal women may prevent age-related bone loss.

Original languageEnglish (US)
Pages (from-to)264-270
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume70
Issue number1
DOIs
StatePublished - Jan 1990
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Dietary modification with dairy products for preventing vertebral bone loss in premenopausal women: A three-year prospective study'. Together they form a unique fingerprint.

  • Cite this