Dietary polyamine intake and risk of colorectal adenomatous polyps

Ashley J. Vargas, Betsy C. Wertheim, Eugene W. Gerner, Cynthia Thomson, Cheryl L. Rock, Patricia A. Thompson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Putrescine, spermidine, and spermine are the polyamines required for human cell growth. The inhibition of ornithine decarboxylase (ODC), which is the rate-limiting enzyme of polyamine biosynthesis, decreases tumor growth and the development of colorectal adenomas. A database was developed to estimate dietary polyamine exposure and relate exposure to health outcomes. Objective: We hypothesized that high polyamine intake would increase risk of colorectal adenoma and that the allelic variation at ODC G>A +316 would modify the association. Design: Polyamine exposure was estimated in subjects pooled (n = 1164) from the control arms of 2 randomized trials for colorectal adenoma prevention [Wheat Bran Fiber low-fiber diet arm (n = 585) and Ursodeoxycholic Acid placebo arm (n = 579)] by using baseline food-frequency questionnaire data. All subjects had to have a diagnosis of colorectal adenoma to be eligible for the trial. Results: A dietary intake of polyamines above the median amount in the study population was associated with 39% increased risk of colorectal adenoma at follow-up (adjusted OR: 1.39; 95% CI: 1.06, 1.83) in the pooled sample. In addition, younger participants (OR: 1.94; 95% CI: 1.23, 3.08), women (OR: 2.43; 95% CI: 1.48, 4.00), and ODC GG genotype carriers (OR: 1.59; 95% CI: 1.00, 2.53) had significantly increased odds of colorectal adenoma if they consumed above-median polyamine amounts. Conclusions: This study showed a role for dietary polyamines in colorectal adenoma risk. Corroboration of these findings would confirm a previously unrecognized, modifiable dietary risk factor for colorectal adenoma.

Original languageEnglish (US)
Pages (from-to)133-141
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume96
Issue number1
DOIs
StatePublished - Jul 2012

Fingerprint

Adenomatous Polyps
Polyamines
Adenoma
Ornithine Decarboxylase
Ursodeoxycholic Acid
Putrescine
Spermidine
Spermine
Dietary Fiber
Growth and Development
Genotype
Placebos
Databases
Diet
Food
Health

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Vargas, A. J., Wertheim, B. C., Gerner, E. W., Thomson, C., Rock, C. L., & Thompson, P. A. (2012). Dietary polyamine intake and risk of colorectal adenomatous polyps. American Journal of Clinical Nutrition, 96(1), 133-141. https://doi.org/10.3945/ajcn.111.030353

Dietary polyamine intake and risk of colorectal adenomatous polyps. / Vargas, Ashley J.; Wertheim, Betsy C.; Gerner, Eugene W.; Thomson, Cynthia; Rock, Cheryl L.; Thompson, Patricia A.

In: American Journal of Clinical Nutrition, Vol. 96, No. 1, 07.2012, p. 133-141.

Research output: Contribution to journalArticle

Vargas, Ashley J. ; Wertheim, Betsy C. ; Gerner, Eugene W. ; Thomson, Cynthia ; Rock, Cheryl L. ; Thompson, Patricia A. / Dietary polyamine intake and risk of colorectal adenomatous polyps. In: American Journal of Clinical Nutrition. 2012 ; Vol. 96, No. 1. pp. 133-141.
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