Dietary source of Ω-3 fatty acids affects endotoxininduced peritoneal macrophage tumor necrosis factor and eicosanoid synthesis

Joan B. Carrick, Rick G. Schnellmann, James N. Moore

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The effect of 8 weeks of feeding diets enriched with corn oil, linseed oil, or menhaden oil on endotoxin- and calcium ionophore (A23187)-induced tumor necrosis factor (TNF) and eicosanold synthesis by rat peritoneal macrophages was determined. The fatty acid composition of macrophage phospholipids and TNF activity and eicosanoid synthesis in response to endotoxin and A23187 were determined. The ratio of Ω 1-6/Ω-3 fatty acids in macrophages from linseed oil or menhaden oil-fed rats decreased approximately 24-and 55-fold, respectively. Basal and endotoxin-induced synthesis of TNF was increased by ingestion of the menhaden oil diet but not by the linseed oil diet. Ingestion of the menhaden oil and linseed oil diets significantly reduced basal, endotoxin-and A23187-induced synthesis of eicosanoids compared with the corn oil group. Ingestion of the menhaden oil diet resulted in a greater decrease in eicosanoid synthesis than the linseed oil diet.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalShock
Volume2
Issue number6
DOIs
StatePublished - Dec 1994
Externally publishedYes

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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