Di(ethylene glycol) vinyl ether: a highly efficient deactivating reagent for olefin metathesis catalysts

Weidong Liu, Paul J. Nichols, Nathan Smith

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

A highly efficient method for deactivating commonly used olefin metathesis catalysts is described. Inexpensive and commercially available di(ethylene glycol) vinyl ether is found to quench both first- and second-generation Grubbs' carbenes in less than 10 min at room temperature. The resulting ruthenium byproducts are readily removed by silica gel purification.

Original languageEnglish (US)
Pages (from-to)6103-6105
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number45
DOIs
StatePublished - Nov 11 2009
Externally publishedYes

Keywords

  • Fisher carbene
  • Metathesis
  • RCM
  • Ruthenium
  • Scavenger

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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