Differences in sleep architecture according to body mass index in children with type 1 diabetes

Salaheddin H. Elrokhsi, Grai P. Bluez, Cindy N. Chin, Mark D. Wheeler, Graciela E. Silva, Michelle M. Perfect

Research output: Contribution to journalReview article

Abstract

Slow wave sleep (SWS), or deep sleep, is thought to be the most restorative stage of sleep and may be of a particular interest in the pathophysiology of obesity. The aim of this study was to investigate differences in sleep architecture based on body mass index (BMI) among a pediatric population with type 1 diabetes mellitus (T1DM). We hypothesized that children with T1DM who are obese would have less SWS than those who are not obese. Of 105 children with T1DM (mean age 13.54 years, 49.5% females) in this study, 19% were obese, 22% were overweight, and 59% had a normal BMI (81% non-obese). The overall SWS% among the participants was 13.2%. In contrast to our hypothesis, there was no significant difference in SWS% between obese and non-obese participants. However, the percent of time spent in rapid eye movement (REM) sleep among obese participants was significantly lower than those who were not obese (P =.022), which remained after adjusting the result for multiple covariates. While we found no significant association between the SWS time and BMI, obese adolescents with T1DM spent less time in REM sleep than those who were not obese. This study adds to the growing body of evidence supporting the importance of addressing sleep in clinical care of youth with T1DM.

Original languageEnglish (US)
Pages (from-to)98-105
Number of pages8
JournalPediatric Diabetes
Volume21
Issue number1
DOIs
StatePublished - Feb 1 2020

Keywords

  • adolescent
  • diabetes
  • obesity
  • sleep architecture

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

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