Different MHC class I alleles compete for presentation of overlapping viral epitopes

Lynda G. Tussey, Sarah Rowland-Jones, Timothy S. Zheng, Matthew J. Androlewicz, Peter Cresswell, Jeffrey A. Frelinger, Andrew J. McMichael

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

We previously identified an HLA-B8+ donor, NW, whose lymphoblestoid cells failed to present a B8-restricted epitope from the influenza A nucleoprotein following viral infection, although added peptide could still be presented. The failure to present through HLA-B8 following viral infection appears to be specific for the NP epitope. Here, we report that donor NW makes an HLA-132702-restricted influenza-specific CTL response to an epitops in the nucleoprotein that overlaps the 138-restricted epitope by 8 aa. Two mechanisms for the failure of this cell line to present the 138-restricted epitope following viral infection are investigated. One is that there is an antigen processing polymorphism specific to the NW cell line, so that there is either preferential generation or preferential transport of the B27702 epitope. The other is that 138 and 132702 compete for a common peptide fragment in the ER and this leads to suboptimal loading of HLA-138.

Original languageEnglish (US)
Pages (from-to)65-77
Number of pages13
JournalImmunity
Volume3
Issue number1
DOIs
StatePublished - Jul 1995
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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  • Cite this

    Tussey, L. G., Rowland-Jones, S., Zheng, T. S., Androlewicz, M. J., Cresswell, P., Frelinger, J. A., & McMichael, A. J. (1995). Different MHC class I alleles compete for presentation of overlapping viral epitopes. Immunity, 3(1), 65-77. https://doi.org/10.1016/1074-7613(95)90159-0