Different tumors in bone each give rise to a distinct pattern of skeletal destruction, bone cancer-related pain behaviors and neurochemical changes in the central nervous system

Mary Ann C Sabino, Nancy M. Luger, David B. Mach, Scott D. Rogers, Matthew J. Schwei, Patrick W Mantyh

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Pain is the most common presenting symptom in patients with bone cancer and bone cancer pain can be both debilitating and difficult to control fully. To begin to understand the mechanisms involved in the generation and maintenance of bone cancer pain, we implanted 3 well-described murine tumor cell lines, 2472 sarcoma, B16 melanoma and C26 colon adenocarcinoma into the femur of immunocompromised C3H-SCID mice. Although each of the tumor cell lines proliferated and completely filled the intramedullary space of the femur within 3 weeks, the location and extent of bone destruction, the type and severity of the pain behaviors and the neurochemical reorganization of the spinal cord was unique to each tumor cell line injected. These data suggest that bone cancer pain is not caused by a single factor such as increased pressure induced by intramedullary tumor growth, but rather that multiple factors are involved in generating and maintaining bone cancer pain.

Original languageEnglish (US)
Pages (from-to)550-558
Number of pages9
JournalInternational Journal of Cancer
Volume104
Issue number5
DOIs
StatePublished - May 1 2003
Externally publishedYes

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Bone Neoplasms
Central Nervous System
Bone and Bones
Tumor Cell Line
Neoplasms
Femur
Pain
Experimental Melanomas
SCID Mice
Inbred C3H Mouse
Sarcoma
Cancer Pain
Spinal Cord
Colon
Adenocarcinoma
Maintenance
Pressure
Growth

Keywords

  • Heterogeneity
  • Metastasis
  • Nociception
  • Osteo lysis
  • Sensitization
  • Tumor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Different tumors in bone each give rise to a distinct pattern of skeletal destruction, bone cancer-related pain behaviors and neurochemical changes in the central nervous system. / Sabino, Mary Ann C; Luger, Nancy M.; Mach, David B.; Rogers, Scott D.; Schwei, Matthew J.; Mantyh, Patrick W.

In: International Journal of Cancer, Vol. 104, No. 5, 01.05.2003, p. 550-558.

Research output: Contribution to journalArticle

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