Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum

Lindi Roberts, Timothy J. Egan, Keith A Joiner, Heinrich C. Hoppe

Research output: Contribution to journalArticle

29 Scopus citations


The effects of quinoline antimalarials on endocytosis by Plasmodium falciparum was investigated by measuring parasite hemoglobin levels, peroxidase uptake, and transport vesicle content. Mefloquine, quinine, and halofantrine inhibited endocytosis, and chloroquine inhibited vesicle trafficking, while amodiaquine shared both effects. Protease inhibitors moderated hemoglobin perturbations, suggesting a common role for heme binding.

Original languageEnglish (US)
Pages (from-to)1840-1842
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Issue number5
Publication statusPublished - May 2008


ASJC Scopus subject areas

  • Pharmacology (medical)

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