Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum

Lindi Roberts, Timothy J. Egan, Keith A. Joiner, Heinrich C. Hoppe

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

The effects of quinoline antimalarials on endocytosis by Plasmodium falciparum was investigated by measuring parasite hemoglobin levels, peroxidase uptake, and transport vesicle content. Mefloquine, quinine, and halofantrine inhibited endocytosis, and chloroquine inhibited vesicle trafficking, while amodiaquine shared both effects. Protease inhibitors moderated hemoglobin perturbations, suggesting a common role for heme binding.

Original languageEnglish (US)
Pages (from-to)1840-1842
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number5
DOIs
StatePublished - May 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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