Differential effects of selective immunotoxic lesions of medial septal cholinergic cells on spatial working and reference memory

Jiemin Shen, Carol A Barnes, Gary L. Wenk, Bruce L. McNaughton

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

The effect of injection into the medial septum of a toxin selective for cholinergic neurons, 192 IgG-saporin, was examined in rats trained to perform 2 versions of the radial 8-arm maze task. Rats were first trained to perform a task with varying delays (0, 1, 2 min) imposed between the 4th correct arm choice and access to all 8-arms. Lesioned rats made significantly more errors in the first 4 choices compared with controls and significantly more errors after delays; however, this effect was not delay dependent. Rats were then trained on a different version of this 8-arm maze task in which they learned to avoid 2 arms that were never baited. There was no treatment effect on acquisition of this task. These data are consistent with the hypothesis that the cholinergic projection to the hippocampus facilitates the acquisition of information into the system responsible for short-term memory for locations visited (spatial working memory) but is not involved in retention of this information. It also appears to play no role in either the acquisition or retention of place-nonreward associations (spatial reference memory).

Original languageEnglish (US)
Pages (from-to)1181-1186
Number of pages6
JournalBehavioral Neuroscience
Volume110
Issue number5
DOIs
StatePublished - Oct 1996

Fingerprint

Short-Term Memory
Cholinergic Agents
Cholinergic Neurons
Information Systems
Hippocampus
Injections
Spatial Memory
Retention (Psychology)
Therapeutics

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Differential effects of selective immunotoxic lesions of medial septal cholinergic cells on spatial working and reference memory. / Shen, Jiemin; Barnes, Carol A; Wenk, Gary L.; McNaughton, Bruce L.

In: Behavioral Neuroscience, Vol. 110, No. 5, 10.1996, p. 1181-1186.

Research output: Contribution to journalArticle

@article{f6046d3876414ca1a84c9e9b2a1f4da4,
title = "Differential effects of selective immunotoxic lesions of medial septal cholinergic cells on spatial working and reference memory",
abstract = "The effect of injection into the medial septum of a toxin selective for cholinergic neurons, 192 IgG-saporin, was examined in rats trained to perform 2 versions of the radial 8-arm maze task. Rats were first trained to perform a task with varying delays (0, 1, 2 min) imposed between the 4th correct arm choice and access to all 8-arms. Lesioned rats made significantly more errors in the first 4 choices compared with controls and significantly more errors after delays; however, this effect was not delay dependent. Rats were then trained on a different version of this 8-arm maze task in which they learned to avoid 2 arms that were never baited. There was no treatment effect on acquisition of this task. These data are consistent with the hypothesis that the cholinergic projection to the hippocampus facilitates the acquisition of information into the system responsible for short-term memory for locations visited (spatial working memory) but is not involved in retention of this information. It also appears to play no role in either the acquisition or retention of place-nonreward associations (spatial reference memory).",
author = "Jiemin Shen and Barnes, {Carol A} and Wenk, {Gary L.} and McNaughton, {Bruce L.}",
year = "1996",
month = "10",
doi = "10.1037/0735-7044.110.5.1181",
language = "English (US)",
volume = "110",
pages = "1181--1186",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "5",

}

TY - JOUR

T1 - Differential effects of selective immunotoxic lesions of medial septal cholinergic cells on spatial working and reference memory

AU - Shen, Jiemin

AU - Barnes, Carol A

AU - Wenk, Gary L.

AU - McNaughton, Bruce L.

PY - 1996/10

Y1 - 1996/10

N2 - The effect of injection into the medial septum of a toxin selective for cholinergic neurons, 192 IgG-saporin, was examined in rats trained to perform 2 versions of the radial 8-arm maze task. Rats were first trained to perform a task with varying delays (0, 1, 2 min) imposed between the 4th correct arm choice and access to all 8-arms. Lesioned rats made significantly more errors in the first 4 choices compared with controls and significantly more errors after delays; however, this effect was not delay dependent. Rats were then trained on a different version of this 8-arm maze task in which they learned to avoid 2 arms that were never baited. There was no treatment effect on acquisition of this task. These data are consistent with the hypothesis that the cholinergic projection to the hippocampus facilitates the acquisition of information into the system responsible for short-term memory for locations visited (spatial working memory) but is not involved in retention of this information. It also appears to play no role in either the acquisition or retention of place-nonreward associations (spatial reference memory).

AB - The effect of injection into the medial septum of a toxin selective for cholinergic neurons, 192 IgG-saporin, was examined in rats trained to perform 2 versions of the radial 8-arm maze task. Rats were first trained to perform a task with varying delays (0, 1, 2 min) imposed between the 4th correct arm choice and access to all 8-arms. Lesioned rats made significantly more errors in the first 4 choices compared with controls and significantly more errors after delays; however, this effect was not delay dependent. Rats were then trained on a different version of this 8-arm maze task in which they learned to avoid 2 arms that were never baited. There was no treatment effect on acquisition of this task. These data are consistent with the hypothesis that the cholinergic projection to the hippocampus facilitates the acquisition of information into the system responsible for short-term memory for locations visited (spatial working memory) but is not involved in retention of this information. It also appears to play no role in either the acquisition or retention of place-nonreward associations (spatial reference memory).

UR - http://www.scopus.com/inward/record.url?scp=0029992569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029992569&partnerID=8YFLogxK

U2 - 10.1037/0735-7044.110.5.1181

DO - 10.1037/0735-7044.110.5.1181

M3 - Article

C2 - 8919021

AN - SCOPUS:0029992569

VL - 110

SP - 1181

EP - 1186

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 5

ER -