Differential expression of extracellular matrix molecules and the α6- integrins in the normal and neoplastic prostate

J. D. Knox, A. E. Cress, V. Clark, L. Manriquez, K. S. Affinito, B. L. Dalkin, R. B. Nagle

Research output: Contribution to journalArticlepeer-review

149 Scopus citations


The epithelial basal lamina composition and integrin expression profile of normal and neoplastic human prostate was characterized using immunohistochemical analysis of frozen samples. The major components of the basal lamina surrounding normal acini were laminin, type IV collagen, entactin, and type VII collagen with variable amounts of tenascin. The basal lamina of neoplastic acini had a similar composition, except for the loss of type VII collagen, which was observed in all grades of carcinoma. The basal cells of the normal prostate express the α6-, β1-, and β4-integrin subunits, suggesting that both the α6β1- and α6β4-integrin complexes are formed. In prostate carcinoma there is a complete loss of β4 expression and the α6- and β1-integrin subunits, which are restricted to the basal and basal lateral surfaces of basal cells, are distributed diffusely throughout the cytoplasmic membrane. The differential expression of type VII collagen and β4 are discussed in relationship to their possible role in tumor progression.

Original languageEnglish (US)
Pages (from-to)167-174
Number of pages8
JournalAmerican Journal of Pathology
Issue number1
StatePublished - 1994

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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