Differential growth and multicellular villi direct proepicardial translocation to the developing mouse heart

Laurel S. Rodgers, Sofia Lalani, Ray B. Runyan, Todd D. Camenisch

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

In the mammalian system the proepicardium (PE) arises from mesothelium of the septum transversum before translocation to the heart where it forms the epicardium and progenitor cells of the coronary vessels. Despite its importance, the process in which PE cells translocate to the myocardium in mammals is not well defined. The current paradigm states that cellular cysts of PE float across the pericardial space and contact the outer surface of the myocardium. This mechanism does not provide a satisfactory explanation for the directionality or localization of PE migration. To better define PE migration, we performed a detailed study of mouse PE development. We provide thorough documentation that redefines the size of the PE migratory field and the mechanism of migration. Our new model incorporates differential growth and direct contact between multicellular PE villi and the myocardium as mechanisms in formation of the epicardium.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalDevelopmental Dynamics
Volume237
Issue number1
DOIs
StatePublished - Jan 1 2008

Keywords

  • Coronary vessels
  • Epicardium
  • Myocardium
  • Proepicardium

ASJC Scopus subject areas

  • Developmental Biology

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