Differential localization of antigonadotropic and vasotocic activities in bovine and rat pineal

Bryant Benson, Mary Jane Matthews, Mac E. Hadley, Stephen Powers, Victor J. Hruby

Research output: Contribution to journalArticle

18 Scopus citations


Bovine pineal glands were separated into stalk and parenchymal portions and extracted separately for both pineal antigonadotropic and neurohypophysial activities. Bioassay of these extracts localized neurohypophysial hormone activity to the stalk and antigonadotropic activity to the pineal parenchyma. Destalked rat pineals were devoid of neurohypophysial hormone activity at the concentrations employed. Whereas the injection of purified extracts containing pineal antigonadotropin reduced ventral prostate weights in mice, vasotocin was without such actions. these results fail to support pineal (parenchymal) localization of vasotocin and a reproductive role for this neurohypophysial peptide.

Original languageEnglish (US)
Pages (from-to)747-754
Number of pages8
JournalLife Sciences
Issue number5
StatePublished - Sep 1 1976


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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