Differential localization of antigonadotropic and vasotocic activities in bovine and rat pineal

Bryant Benson, Mary Jane Matthews, Mac E. Hadley, Stephen Powers, Victor J Hruby

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Bovine pineal glands were separated into stalk and parenchymal portions and extracted separately for both pineal antigonadotropic and neurohypophysial activities. Bioassay of these extracts localized neurohypophysial hormone activity to the stalk and antigonadotropic activity to the pineal parenchyma. Destalked rat pineals were devoid of neurohypophysial hormone activity at the concentrations employed. Whereas the injection of purified extracts containing pineal antigonadotropin reduced ventral prostate weights in mice, vasotocin was without such actions. these results fail to support pineal (parenchymal) localization of vasotocin and a reproductive role for this neurohypophysial peptide.

Original languageEnglish (US)
Pages (from-to)747-754
Number of pages8
JournalLife Sciences
Volume19
Issue number5
DOIs
StatePublished - Sep 1 1976

Fingerprint

Posterior Pituitary Hormones
Vasotocin
Rats
Pineal Gland
Bioassay
Biological Assay
Prostate
Weights and Measures
Injections

ASJC Scopus subject areas

  • Pharmacology

Cite this

Differential localization of antigonadotropic and vasotocic activities in bovine and rat pineal. / Benson, Bryant; Jane Matthews, Mary; Hadley, Mac E.; Powers, Stephen; Hruby, Victor J.

In: Life Sciences, Vol. 19, No. 5, 01.09.1976, p. 747-754.

Research output: Contribution to journalArticle

Benson, Bryant ; Jane Matthews, Mary ; Hadley, Mac E. ; Powers, Stephen ; Hruby, Victor J. / Differential localization of antigonadotropic and vasotocic activities in bovine and rat pineal. In: Life Sciences. 1976 ; Vol. 19, No. 5. pp. 747-754.
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