Differential regulation of endothelial cell barrier function

Jeffrey R. Jacobson, Steven M. Dudek, Joe GN Garcia

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The endothelium serves as a semipermeable barrier separating the circulation from the surrounding interstitium. Its luminal surface is coated with a negatively charged glycocalyx comprised of membrane-bound proteoglycans and glycoproteins. The tight apposition of individual endothelial cells (ECs) with neighboring cells via intercellular junctions acts as a significant determinant of basal endothelial barrier function. Separately, focal adhesions, the integrin-based linkages between the extracellular matrix and the endothelial cytoskeleton, provide strong tethering of the endothelium to the vessel wall, a process that also contributes to barrier integrity.

Original languageEnglish (US)
Title of host publicationEndothelial Cells in Health and Disease
PublisherCRC Press
Pages217-228
Number of pages12
ISBN (Electronic)9780203025956
ISBN (Print)0824754247, 9780824754242
StatePublished - Jan 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Jacobson, J. R., Dudek, S. M., & Garcia, J. GN. (2005). Differential regulation of endothelial cell barrier function. In Endothelial Cells in Health and Disease (pp. 217-228). CRC Press.