Differential regulation of muscarinic agonist binding sites following chronic cholinesterase inhibition

M. H. Smit, F. J. Ehlert, S. Yamamura, W. R. Roeske, H. I. Yamamura

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The symptoms of cholinergic stimulation caused acutely by the organophosphorus cholinesterase (ChE) inhibitor, paraoxon, gradually diminish after chronic administration of this agent. To assess the role of muscarinic receptor mediated subsensitivity in the development of tolerance to paraoxon administration, we measured the binding properties of central muscarinic receptors from rats chronically treated with paraoxon. The results indicate that chronic ChE inhibition decreases the density of central muscarinic receptors and establish that tolerance to chronic paraoxon administration is, in part, mediated via changes in muscarinic receptors.

Original languageEnglish (US)
Pages (from-to)379-380
Number of pages2
JournalEuropean Journal of Pharmacology
Volume66
Issue number4
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Paraoxon
Muscarinic Agonists
Cholinesterases
Muscarinic Receptors
Binding Sites
Cholinesterase Inhibitors
Cholinergic Agents

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Differential regulation of muscarinic agonist binding sites following chronic cholinesterase inhibition. / Smit, M. H.; Ehlert, F. J.; Yamamura, S.; Roeske, W. R.; Yamamura, H. I.

In: European Journal of Pharmacology, Vol. 66, No. 4, 1980, p. 379-380.

Research output: Contribution to journalArticle

Smit, M. H. ; Ehlert, F. J. ; Yamamura, S. ; Roeske, W. R. ; Yamamura, H. I. / Differential regulation of muscarinic agonist binding sites following chronic cholinesterase inhibition. In: European Journal of Pharmacology. 1980 ; Vol. 66, No. 4. pp. 379-380.
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