Differential sorting and post-secretory targeting of proteins in parasitic invasion

Huân M. Ngô, Heinrich C. Hoppe, Keith A Joiner

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Toxoplasma gondii uses a highly coordinated arsenal of three structurally and biochemically distinct secretory granules to invade and develop in a wide range of host cells. Proteins of these secretory granules are sorted to strategic subcellular locations using distinctive sorting signals and are then triggered differentially for exocytosis. These secreted proteins are subsequently targeted and inserted into membrane domains.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalTrends in Cell Biology
Volume10
Issue number2
DOIs
StatePublished - Feb 1 2000
Externally publishedYes

Fingerprint

Secretory Vesicles
Protein Transport
Toxoplasma
Exocytosis
Proteins
Membranes

ASJC Scopus subject areas

  • Cell Biology

Cite this

Differential sorting and post-secretory targeting of proteins in parasitic invasion. / Ngô, Huân M.; Hoppe, Heinrich C.; Joiner, Keith A.

In: Trends in Cell Biology, Vol. 10, No. 2, 01.02.2000, p. 67-72.

Research output: Contribution to journalArticle

@article{7973988b6d904abc905294c64eeabb66,
title = "Differential sorting and post-secretory targeting of proteins in parasitic invasion",
abstract = "Toxoplasma gondii uses a highly coordinated arsenal of three structurally and biochemically distinct secretory granules to invade and develop in a wide range of host cells. Proteins of these secretory granules are sorted to strategic subcellular locations using distinctive sorting signals and are then triggered differentially for exocytosis. These secreted proteins are subsequently targeted and inserted into membrane domains.",
author = "Ng{\^o}, {Hu{\^a}n M.} and Hoppe, {Heinrich C.} and Joiner, {Keith A}",
year = "2000",
month = "2",
day = "1",
doi = "10.1016/S0962-8924(99)01698-0",
language = "English (US)",
volume = "10",
pages = "67--72",
journal = "Trends in Cell Biology",
issn = "0962-8924",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Differential sorting and post-secretory targeting of proteins in parasitic invasion

AU - Ngô, Huân M.

AU - Hoppe, Heinrich C.

AU - Joiner, Keith A

PY - 2000/2/1

Y1 - 2000/2/1

N2 - Toxoplasma gondii uses a highly coordinated arsenal of three structurally and biochemically distinct secretory granules to invade and develop in a wide range of host cells. Proteins of these secretory granules are sorted to strategic subcellular locations using distinctive sorting signals and are then triggered differentially for exocytosis. These secreted proteins are subsequently targeted and inserted into membrane domains.

AB - Toxoplasma gondii uses a highly coordinated arsenal of three structurally and biochemically distinct secretory granules to invade and develop in a wide range of host cells. Proteins of these secretory granules are sorted to strategic subcellular locations using distinctive sorting signals and are then triggered differentially for exocytosis. These secreted proteins are subsequently targeted and inserted into membrane domains.

UR - http://www.scopus.com/inward/record.url?scp=0034141202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034141202&partnerID=8YFLogxK

U2 - 10.1016/S0962-8924(99)01698-0

DO - 10.1016/S0962-8924(99)01698-0

M3 - Article

C2 - 10652517

AN - SCOPUS:0034141202

VL - 10

SP - 67

EP - 72

JO - Trends in Cell Biology

JF - Trends in Cell Biology

SN - 0962-8924

IS - 2

ER -