Differential sorting and post-secretory targeting of proteins in parasitic invasion

Huân M. Ngô, Heinrich C. Hoppe, Keith A Joiner

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Toxoplasma gondii uses a highly coordinated arsenal of three structurally and biochemically distinct secretory granules to invade and develop in a wide range of host cells. Proteins of these secretory granules are sorted to strategic subcellular locations using distinctive sorting signals and are then triggered differentially for exocytosis. These secreted proteins are subsequently targeted and inserted into membrane domains.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalTrends in Cell Biology
Volume10
Issue number2
DOIs
Publication statusPublished - Feb 1 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Cell Biology

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