Diffuse small cleaved-cell lymphoma: A heterogeneous disease with distinct immunobiologic subsets

Catherine P. Leith, Catherine M. Spier, Thomas M. Grogan, Guillermo Gonzales, Catherine S. Rangel, James A. Rybski, Monika Matzner, Thomas P. Miller

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Purpose and Methods: Diffuse small cleaved-cell lymphoma (DSCL) is a relatively uncommon non-Hodgkin's lymphoma (NHL) in the United States and has not been the subject of recent in-depth study of factors predictive of outcome. It is unique among the NHL of intermediate grade because there is no evidence of a curable subset of patients. To investigate whether any laboratory data might predict outcome, we studied 33 cases collected during a 12-year period and correlated morphology, immunohistochemistry, and serum lactate dehydrogenase (LDH) with clinical data and outcome. Results: We found that proliferative rate (Ki-67), cell lineage (T v B cell), and serum LDH were associated with significant differences in survival. A Ki-67 value ≥ 20% was associated with a median survival of 20 months compared with 80 months for lower values (P = .0002); patients with tumors of T-cell lineage had a median survival of 20 months compared with 40 months for those with B-cell neoplasms (P = .0143); and a serum LDH greater than 225 IU/L was associated with a median survival of 8 months compared with 40 months for lower LDH levels (P = .0004). Blastoid morphology was also linked to a trend toward poor outcome (P = .08). Neither a history of low-grade lymphoma nor the presence of residual immunologically detectable follicles influenced outcome (P = .93 and .97, respectively). Conclusion: We conclude that high Ki-67, high LDH, and T-cell lineage each identify DSCL patients with poor outcome.

Original languageEnglish (US)
Pages (from-to)1259-1265
Number of pages7
JournalJournal of Clinical Oncology
Volume10
Issue number8
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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