Difluoromethylornithine: The proof is in the polyamines

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

In this issue (beginning on page 1368), Kreul and colleagues report a retrospective review of long-term efficacy and toxicity for subjects participating in a phase III study of difluoromethylornithine (DFMO) for prevention of nonmelanoma skin cancer (NMSC). They conclude that those treated with DFMO had a nonsignificant, persistent decrease in NMSC after completion of treatment and that treatment with DFMO did not result in late toxicity after the discontinuation of treatment. We review the data on DFMO as a chemopreventive agent for skin and other cancers, discuss the necessary qualities of a cancer chemopreventive agent, and reflect on the requirements for a well-conducted cancer chemoprevention study, including the rationale for long-term follow-up in cancer prevention studies.

Original languageEnglish (US)
Pages (from-to)1341-1344
Number of pages4
JournalCancer Prevention Research
Volume5
Issue number12
DOIs
StatePublished - Dec 1 2012

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Difluoromethylornithine: The proof is in the polyamines'. Together they form a unique fingerprint.

  • Cite this