Digitoxin-quinidine interaction: Pharmacokinetic evaluation

Paul E Fenster, J. R. Powell, P. E. Graves, K. A. Conrad, W. D. Hager, Steven Goldman, F. I. Marcus

Research output: Contribution to journalArticle

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Abstract

The effect of quinidine on digitoxin single-dose pharmacokinetics was evaluated in five healthy adults. Blood was collected for 3 weeks, and a complete urine collection was obtained for 4 days, after a single intravenous dose of digitoxin. the protocol was conducted once while each subject was taking oral quinidine, for 3 weeks, and then repeated 10 days after discontinuing quinidine treatment. Quinidine induced the following changes in digitoxin pharmacokinetics: Elimination half-life was prolonged from 174 ± 25 to 261 ± 58 hours (p<0.02); total body clearance decreased from 1.54 ± 0.40 to 1.09 ± 0.31 mL/h.kg (p<0.05); renal clearance decreased from 0.65 ± 0.07 to 0.46 ± 0.17 mL/h.kg (p<0.05). Digitoxin volume of distribution and protein binding were unaltered by quinidine. Quinidine caused a rise in serum digitoxin levels. Digitoxin total body clearance was decreased by quinidine to an extent comparable to that reported for digoxin; however, the mechanism of the interaction with the two digitalis glycosides may, in part, be different.

Original languageEnglish (US)
Pages (from-to)698-701
Number of pages4
JournalAnnals of Internal Medicine
Volume93
Issue number5
StatePublished - 1980

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Digitoxin
Quinidine
Pharmacokinetics
Digitalis Glycosides
Urine Specimen Collection
Digoxin
Protein Binding
Half-Life
Kidney
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fenster, P. E., Powell, J. R., Graves, P. E., Conrad, K. A., Hager, W. D., Goldman, S., & Marcus, F. I. (1980). Digitoxin-quinidine interaction: Pharmacokinetic evaluation. Annals of Internal Medicine, 93(5), 698-701.

Digitoxin-quinidine interaction : Pharmacokinetic evaluation. / Fenster, Paul E; Powell, J. R.; Graves, P. E.; Conrad, K. A.; Hager, W. D.; Goldman, Steven; Marcus, F. I.

In: Annals of Internal Medicine, Vol. 93, No. 5, 1980, p. 698-701.

Research output: Contribution to journalArticle

Fenster, PE, Powell, JR, Graves, PE, Conrad, KA, Hager, WD, Goldman, S & Marcus, FI 1980, 'Digitoxin-quinidine interaction: Pharmacokinetic evaluation', Annals of Internal Medicine, vol. 93, no. 5, pp. 698-701.
Fenster PE, Powell JR, Graves PE, Conrad KA, Hager WD, Goldman S et al. Digitoxin-quinidine interaction: Pharmacokinetic evaluation. Annals of Internal Medicine. 1980;93(5):698-701.
Fenster, Paul E ; Powell, J. R. ; Graves, P. E. ; Conrad, K. A. ; Hager, W. D. ; Goldman, Steven ; Marcus, F. I. / Digitoxin-quinidine interaction : Pharmacokinetic evaluation. In: Annals of Internal Medicine. 1980 ; Vol. 93, No. 5. pp. 698-701.
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