Digoxin disposition kinetics in dogs before and during azotemia

K. D. Gierke, D. Perrier, Michael Mayersohn, F. I. Marcus

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the disposition kinetics of digoxin after the administration of a single intravenous dose to the same dogs before and during azotemia. The digoxin plasma concentration-time data were fitted to a multicompartment model using nonlinear regression analysis. During azotemia, the biological half-life of digoxin was prolonged in six of seven dogs, while digoxin renal clearance, body clearance and apparent volume of distribution were significantly decreased. There was a corresponding increase in the apparent volume of the 'central' compartment of digoxin. Approximately 45% of a digoxin dose was excreted by the kidney in these animals indicating a substantial nonrenal component to digoxin elimination in the dog. This nonrenal elimination did not change during azotemia, despite a decrease in renal clearance by 61%.

Original languageEnglish (US)
Pages (from-to)459-464
Number of pages6
JournalJournal of Pharmacology and Experimental Therapeutics
Volume205
Issue number2
StatePublished - 1978

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Azotemia
Digoxin
Dogs
Kidney
Half-Life
Regression Analysis

ASJC Scopus subject areas

  • Pharmacology

Cite this

Digoxin disposition kinetics in dogs before and during azotemia. / Gierke, K. D.; Perrier, D.; Mayersohn, Michael; Marcus, F. I.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 205, No. 2, 1978, p. 459-464.

Research output: Contribution to journalArticle

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