Digoxin disposition kinetics in dogs before and during azotemia

K. D. Gierke, D. Perrier, M. Mayersohn, F. I. Marcus

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The purpose of this study was to evaluate the disposition kinetics of digoxin after the administration of a single intravenous dose to the same dogs before and during azotemia. The digoxin plasma concentration-time data were fitted to a multicompartment model using nonlinear regression analysis. During azotemia, the biological half-life of digoxin was prolonged in six of seven dogs, while digoxin renal clearance, body clearance and apparent volume of distribution were significantly decreased. There was a corresponding increase in the apparent volume of the 'central' compartment of digoxin. Approximately 45% of a digoxin dose was excreted by the kidney in these animals indicating a substantial nonrenal component to digoxin elimination in the dog. This nonrenal elimination did not change during azotemia, despite a decrease in renal clearance by 61%.

Original languageEnglish (US)
Pages (from-to)459-464
Number of pages6
JournalJournal of Pharmacology and Experimental Therapeutics
Volume205
Issue number2
StatePublished - 1978

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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