Digoxin-quinidine interaction in patients with chronic renal failure

Paul E Fenster, W. D. Hager, D. Perrier, J. R. Powell, P. E. Graves, U. F. Michael

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We evaluated the effect of quinidine on digoxin pharmacokinetics in six patients with severe renal failure. Quinidine reduced the total body clearance of digoxin from 1.87 to 1.06 l/hour (p < 0.001), and prolonged the digoxin half-life of elimination from 5.20 to 9.61 days (p < 0.01). The digoxin volume of distribution was unchanged. Renal clearance of digoxin was negligible; thus, the decrease in total body clearance was due to a decrease in the nonrenal clearance of digoxin. The mean trough serum concentrations of quinidine ranged from 1.0 to 3.0 μg/ml. We conclude that in patients with chronic renal failure, the dose of digoxin should be decreased by 50% if quinidine therapy is initiated.

Original languageEnglish (US)
Pages (from-to)1277-1280
Number of pages4
JournalCirculation
Volume66
Issue number6 I
StatePublished - 1982

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Quinidine
Digoxin
Chronic Kidney Failure
Renal Insufficiency
Half-Life
Pharmacokinetics
Kidney
Serum

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Fenster, P. E., Hager, W. D., Perrier, D., Powell, J. R., Graves, P. E., & Michael, U. F. (1982). Digoxin-quinidine interaction in patients with chronic renal failure. Circulation, 66(6 I), 1277-1280.

Digoxin-quinidine interaction in patients with chronic renal failure. / Fenster, Paul E; Hager, W. D.; Perrier, D.; Powell, J. R.; Graves, P. E.; Michael, U. F.

In: Circulation, Vol. 66, No. 6 I, 1982, p. 1277-1280.

Research output: Contribution to journalArticle

Fenster, PE, Hager, WD, Perrier, D, Powell, JR, Graves, PE & Michael, UF 1982, 'Digoxin-quinidine interaction in patients with chronic renal failure', Circulation, vol. 66, no. 6 I, pp. 1277-1280.
Fenster PE, Hager WD, Perrier D, Powell JR, Graves PE, Michael UF. Digoxin-quinidine interaction in patients with chronic renal failure. Circulation. 1982;66(6 I):1277-1280.
Fenster, Paul E ; Hager, W. D. ; Perrier, D. ; Powell, J. R. ; Graves, P. E. ; Michael, U. F. / Digoxin-quinidine interaction in patients with chronic renal failure. In: Circulation. 1982 ; Vol. 66, No. 6 I. pp. 1277-1280.
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