Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5

Allison J. Nipper, Megan J Smithey, Raj C. Shah, David H. Canaday, Alan L. Landay

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Individuals over the age of 65 comprise a substantial portion of the world population and become more susceptible to vaccine-preventable infections with age as vaccination response diminishes. The underlying reason for this impaired vaccine response in older individuals is not entirely clear. We evaluated potential differences in phenotypic and functional responses of B cells from healthy younger (22-45years) and older (64-95years) individuals that may associate with a diminished antibody response to influenza vaccination. We report that age is associated with expansion of atypical memory B cells (CD10-CD20+CD21-CD27-) and an age-associated B cell (ABC, CD21-T-bet+CD11c+) phenotype. Reduced expression of PAX5 was also seen in older individuals. Poor influenza-specific antibody production following vaccination was associated with low PAX5 expression and a distinct composition of the ABC compartment. Collectively, these findings demonstrate that the characteristics of the ABC populations of older individuals are associated with antibody production following influenza vaccination.

Original languageEnglish (US)
JournalClinical Immunology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Human Influenza
Antibody Formation
Vaccination
B-Lymphocytes
Population
Vaccines
Population Characteristics
Phenotype
Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5. / Nipper, Allison J.; Smithey, Megan J; Shah, Raj C.; Canaday, David H.; Landay, Alan L.

In: Clinical Immunology, 01.01.2018.

Research output: Contribution to journalArticle

@article{fb9e6fb90aa141379e806b6d2a6e12fb,
title = "Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5",
abstract = "Individuals over the age of 65 comprise a substantial portion of the world population and become more susceptible to vaccine-preventable infections with age as vaccination response diminishes. The underlying reason for this impaired vaccine response in older individuals is not entirely clear. We evaluated potential differences in phenotypic and functional responses of B cells from healthy younger (22-45years) and older (64-95years) individuals that may associate with a diminished antibody response to influenza vaccination. We report that age is associated with expansion of atypical memory B cells (CD10-CD20+CD21-CD27-) and an age-associated B cell (ABC, CD21-T-bet+CD11c+) phenotype. Reduced expression of PAX5 was also seen in older individuals. Poor influenza-specific antibody production following vaccination was associated with low PAX5 expression and a distinct composition of the ABC compartment. Collectively, these findings demonstrate that the characteristics of the ABC populations of older individuals are associated with antibody production following influenza vaccination.",
author = "Nipper, {Allison J.} and Smithey, {Megan J} and Shah, {Raj C.} and Canaday, {David H.} and Landay, {Alan L.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.clim.2018.02.003",
language = "English (US)",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5

AU - Nipper, Allison J.

AU - Smithey, Megan J

AU - Shah, Raj C.

AU - Canaday, David H.

AU - Landay, Alan L.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Individuals over the age of 65 comprise a substantial portion of the world population and become more susceptible to vaccine-preventable infections with age as vaccination response diminishes. The underlying reason for this impaired vaccine response in older individuals is not entirely clear. We evaluated potential differences in phenotypic and functional responses of B cells from healthy younger (22-45years) and older (64-95years) individuals that may associate with a diminished antibody response to influenza vaccination. We report that age is associated with expansion of atypical memory B cells (CD10-CD20+CD21-CD27-) and an age-associated B cell (ABC, CD21-T-bet+CD11c+) phenotype. Reduced expression of PAX5 was also seen in older individuals. Poor influenza-specific antibody production following vaccination was associated with low PAX5 expression and a distinct composition of the ABC compartment. Collectively, these findings demonstrate that the characteristics of the ABC populations of older individuals are associated with antibody production following influenza vaccination.

AB - Individuals over the age of 65 comprise a substantial portion of the world population and become more susceptible to vaccine-preventable infections with age as vaccination response diminishes. The underlying reason for this impaired vaccine response in older individuals is not entirely clear. We evaluated potential differences in phenotypic and functional responses of B cells from healthy younger (22-45years) and older (64-95years) individuals that may associate with a diminished antibody response to influenza vaccination. We report that age is associated with expansion of atypical memory B cells (CD10-CD20+CD21-CD27-) and an age-associated B cell (ABC, CD21-T-bet+CD11c+) phenotype. Reduced expression of PAX5 was also seen in older individuals. Poor influenza-specific antibody production following vaccination was associated with low PAX5 expression and a distinct composition of the ABC compartment. Collectively, these findings demonstrate that the characteristics of the ABC populations of older individuals are associated with antibody production following influenza vaccination.

UR - http://www.scopus.com/inward/record.url?scp=85042080390&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042080390&partnerID=8YFLogxK

U2 - 10.1016/j.clim.2018.02.003

DO - 10.1016/j.clim.2018.02.003

M3 - Article

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

ER -