Direct and glia-mediated effects of GABA on development of central olfactory neurons

Heather S. Mallory, Nicholas J. Gibson, Jon H. Hayashi, Alan J Nighorn, Lynne A Oland

Research output: Contribution to journalArticle

Abstract

Previously studied for its role in processing olfactory information in the antennal lobe, GABA also may shape development of the olfactory pathway, acting either through or on glial cells. Early in development, the dendrites of GABAergic neurons extend to the glial border that surrounds the nascent olfactory lobe neuropil. These neuropil glia express both GABAA and GABAB receptors, about half of the glia in acute cultures responded to GABA with small outward currents, and about a third responded with small transient increases in intracellular calcium. The neuronal classes that express GABA in vivo, the local interneurons and a subset of projection neurons, also do so in culture. Exposure to GABA in culture increased the size and complexity of local interneurons, but had no effect on glial morphology. The presence of glia alone did not affect neuronal morphology, but in the presence of both glia and GABA, the growth-enhancing effects of GABA on cultured antennal lobe neurons were eliminated. Contact between the glial cells and the neurons was not necessary. Operating in vivo, these antagonistic effects, one direct and one glia mediated, could help to sculpt the densely branched, tufted arbors that are characteristic of neurons innervating olfactory glomeruli.

Original languageEnglish (US)
Pages (from-to)143-161
Number of pages19
JournalNeuron Glia Biology
Volume7
Issue number2-4
DOIs
StatePublished - May 2011

Fingerprint

Neuroglia
gamma-Aminobutyric Acid
Neurons
Neuropil
Interneurons
GABAergic Neurons
Olfactory Pathways
Olfactory Bulb
GABA-A Receptors
Dendrites
Automatic Data Processing
Calcium
Growth

Keywords

  • Antennal lobe
  • GABA current
  • GABA receptors
  • Glial cells
  • Manduca sexta

ASJC Scopus subject areas

  • Cell Biology
  • Cellular and Molecular Neuroscience

Cite this

Direct and glia-mediated effects of GABA on development of central olfactory neurons. / Mallory, Heather S.; Gibson, Nicholas J.; Hayashi, Jon H.; Nighorn, Alan J; Oland, Lynne A.

In: Neuron Glia Biology, Vol. 7, No. 2-4, 05.2011, p. 143-161.

Research output: Contribution to journalArticle

Mallory, Heather S. ; Gibson, Nicholas J. ; Hayashi, Jon H. ; Nighorn, Alan J ; Oland, Lynne A. / Direct and glia-mediated effects of GABA on development of central olfactory neurons. In: Neuron Glia Biology. 2011 ; Vol. 7, No. 2-4. pp. 143-161.
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