Direct charged-particle imaging system using an ultra-thin phosphor: Physical characterization and dynamic applications

Liying Chen, Lisa S. Gobar, Negar G. Knowles, Donald W. Wilson, Harrison H Barrett

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Imaging β rays in vivo will help to advance microdosimetry and radiopharmaceutical development. In an earlier paper , we reported a newly developed system capable of directly imaging high-energy electron emissions in small animals in vivo. In this paper, we have thoroughly characterized the performance of the system. We have measured the sensitivity and detectability and the spatial resolution at various magnifications, as well as the linearity of the system. The system has also demonstrated the capability of directly detecting conversion electrons and positrons as well as β rays. The system has been applied to dynamically image spatiotemporal 18 F-Fluorodeoxyglucose (FDG) uptake distributions in xenograft small tumors in dorsal window chambers on mice in vivo. Heterogeneity in FDG uptake in millimeter-sized tumors has been observed.

Original languageEnglish (US)
Article number5280506
Pages (from-to)2628-2635
Number of pages8
JournalIEEE Transactions on Nuclear Science
Volume56
Issue number5
DOIs
StatePublished - Oct 2009

Fingerprint

Charged particles
Imaging systems
Phosphors
phosphors
Tumors
rays
charged particles
tumors
Imaging techniques
Electron emission
Positrons
magnification
high energy electrons
electron emission
linearity
mice
animals
positrons
Animals
spatial resolution

Keywords

  • Charged particle
  • Dynamic imaging
  • In vivo
  • Resolution
  • Sensitivity

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering
  • Nuclear and High Energy Physics

Cite this

Direct charged-particle imaging system using an ultra-thin phosphor : Physical characterization and dynamic applications. / Chen, Liying; Gobar, Lisa S.; Knowles, Negar G.; Wilson, Donald W.; Barrett, Harrison H.

In: IEEE Transactions on Nuclear Science, Vol. 56, No. 5, 5280506, 10.2009, p. 2628-2635.

Research output: Contribution to journalArticle

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