Direct charged-particle imaging system using an ultra-thin phosphor: Physical characterization and dynamic applications

Liying Chen, Lisa S. Gobar, Negar G. Knowles, Donald W. Wilson, Harrison H. Barrett

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Imaging β rays in vivo will help to advance microdosimetry and radiopharmaceutical development. In an earlier paper , we reported a newly developed system capable of directly imaging high-energy electron emissions in small animals in vivo. In this paper, we have thoroughly characterized the performance of the system. We have measured the sensitivity and detectability and the spatial resolution at various magnifications, as well as the linearity of the system. The system has also demonstrated the capability of directly detecting conversion electrons and positrons as well as β rays. The system has been applied to dynamically image spatiotemporal 18 F-Fluorodeoxyglucose (FDG) uptake distributions in xenograft small tumors in dorsal window chambers on mice in vivo. Heterogeneity in FDG uptake in millimeter-sized tumors has been observed.

Original languageEnglish (US)
Article number5280506
Pages (from-to)2628-2635
Number of pages8
JournalIEEE Transactions on Nuclear Science
Volume56
Issue number5
DOIs
StatePublished - Oct 1 2009

Keywords

  • Charged particle
  • Dynamic imaging
  • In vivo
  • Resolution
  • Sensitivity

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering

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