Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense

Ilhem Messaoudi, Jose A. Guevara Patiño, Ruben Dyall, Joël LeMaoult, Janko Nikolich-Žugich

Research output: Contribution to journalArticlepeer-review

236 Scopus citations

Abstract

Major histocompatibility complex (mhc)-encoded molecules govern immune responses by presenting antigenic peptides to T cells. The extensive polymorphism of genes encoding these molecules is believed to enhance immune defense by broadening the array of antigenic peptides available for T cell recognition, but direct evidence supporting the importance of this mechanism in combating pathogens is limited. Here we link mhc polymorphism-driven diversification of the cytotoxic T lymphocyte (CTL) repertoire to the generation of high-avidity, protective antiviral T cells and to superior antiviral defense. Thus, much of the beneficial effect of the mhc polymorphism in immune defense may be due to its critical influence on the properties of the selected CTL repertoire.

Original languageEnglish (US)
Pages (from-to)1797-1800
Number of pages4
JournalScience
Volume298
Issue number5599
DOIs
StatePublished - Nov 29 2002

ASJC Scopus subject areas

  • General

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