Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense

Ilhem Messaoudi, Jose A. Guevara Patiño, Ruben Dyall, Joël LeMaoult, Janko Nikolich-Zugich

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

Major histocompatibility complex (mhc)-encoded molecules govern immune responses by presenting antigenic peptides to T cells. The extensive polymorphism of genes encoding these molecules is believed to enhance immune defense by broadening the array of antigenic peptides available for T cell recognition, but direct evidence supporting the importance of this mechanism in combating pathogens is limited. Here we link mhc polymorphism-driven diversification of the cytotoxic T lymphocyte (CTL) repertoire to the generation of high-avidity, protective antiviral T cells and to superior antiviral defense. Thus, much of the beneficial effect of the mhc polymorphism in immune defense may be due to its critical influence on the properties of the selected CTL repertoire.

Original languageEnglish (US)
Pages (from-to)1797-1800
Number of pages4
JournalScience
Volume298
Issue number5599
DOIs
StatePublished - Nov 29 2002
Externally publishedYes

Fingerprint

Major Histocompatibility Complex
Peptide T
Cytotoxic T-Lymphocytes
T-Lymphocytes
Antiviral Agents
Genes

ASJC Scopus subject areas

  • General

Cite this

Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense. / Messaoudi, Ilhem; Guevara Patiño, Jose A.; Dyall, Ruben; LeMaoult, Joël; Nikolich-Zugich, Janko.

In: Science, Vol. 298, No. 5599, 29.11.2002, p. 1797-1800.

Research output: Contribution to journalArticle

Messaoudi, I, Guevara Patiño, JA, Dyall, R, LeMaoult, J & Nikolich-Zugich, J 2002, 'Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense', Science, vol. 298, no. 5599, pp. 1797-1800. https://doi.org/10.1126/science.1076064
Messaoudi, Ilhem ; Guevara Patiño, Jose A. ; Dyall, Ruben ; LeMaoult, Joël ; Nikolich-Zugich, Janko. / Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense. In: Science. 2002 ; Vol. 298, No. 5599. pp. 1797-1800.
@article{7304102a8370408d8710ed9eb5e8e0e1,
title = "Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense",
abstract = "Major histocompatibility complex (mhc)-encoded molecules govern immune responses by presenting antigenic peptides to T cells. The extensive polymorphism of genes encoding these molecules is believed to enhance immune defense by broadening the array of antigenic peptides available for T cell recognition, but direct evidence supporting the importance of this mechanism in combating pathogens is limited. Here we link mhc polymorphism-driven diversification of the cytotoxic T lymphocyte (CTL) repertoire to the generation of high-avidity, protective antiviral T cells and to superior antiviral defense. Thus, much of the beneficial effect of the mhc polymorphism in immune defense may be due to its critical influence on the properties of the selected CTL repertoire.",
author = "Ilhem Messaoudi and {Guevara Pati{\~n}o}, {Jose A.} and Ruben Dyall and Jo{\"e}l LeMaoult and Janko Nikolich-Zugich",
year = "2002",
month = "11",
day = "29",
doi = "10.1126/science.1076064",
language = "English (US)",
volume = "298",
pages = "1797--1800",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5599",

}

TY - JOUR

T1 - Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense

AU - Messaoudi, Ilhem

AU - Guevara Patiño, Jose A.

AU - Dyall, Ruben

AU - LeMaoult, Joël

AU - Nikolich-Zugich, Janko

PY - 2002/11/29

Y1 - 2002/11/29

N2 - Major histocompatibility complex (mhc)-encoded molecules govern immune responses by presenting antigenic peptides to T cells. The extensive polymorphism of genes encoding these molecules is believed to enhance immune defense by broadening the array of antigenic peptides available for T cell recognition, but direct evidence supporting the importance of this mechanism in combating pathogens is limited. Here we link mhc polymorphism-driven diversification of the cytotoxic T lymphocyte (CTL) repertoire to the generation of high-avidity, protective antiviral T cells and to superior antiviral defense. Thus, much of the beneficial effect of the mhc polymorphism in immune defense may be due to its critical influence on the properties of the selected CTL repertoire.

AB - Major histocompatibility complex (mhc)-encoded molecules govern immune responses by presenting antigenic peptides to T cells. The extensive polymorphism of genes encoding these molecules is believed to enhance immune defense by broadening the array of antigenic peptides available for T cell recognition, but direct evidence supporting the importance of this mechanism in combating pathogens is limited. Here we link mhc polymorphism-driven diversification of the cytotoxic T lymphocyte (CTL) repertoire to the generation of high-avidity, protective antiviral T cells and to superior antiviral defense. Thus, much of the beneficial effect of the mhc polymorphism in immune defense may be due to its critical influence on the properties of the selected CTL repertoire.

UR - http://www.scopus.com/inward/record.url?scp=2242419092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2242419092&partnerID=8YFLogxK

U2 - 10.1126/science.1076064

DO - 10.1126/science.1076064

M3 - Article

C2 - 12459592

AN - SCOPUS:2242419092

VL - 298

SP - 1797

EP - 1800

JO - Science

JF - Science

SN - 0036-8075

IS - 5599

ER -