Disassembly of myofibrils in adult cardiomyocytes during dedifferentiation

Honghai Liu, Wan Qin, Yonghong Shao, Zhonghai Wang, Huaxiao Yang, Raymond B. Runyan, Thomas K. Borg, Bruce Z. Gao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Using hybrid TPEF-SHG imaging and immunocytological techniques, we studied dedifferentiation of adult cardiomyocytes. First, the myofibrils shrank to shorten the sarcomere length. At the cell ends, the striated pattern of myosin filaments began to dissociate; at the center of the cell, the striated pattern of alpha-actinin first faded away and reappeared near the cell membrane during dedifferentiation. The results suggest that when freshly isolated adult cardiomyocytes are used to model cardiac muscle, the end-to-end connection may be important to maintain their striated myofibrillar structure and rod-shape morphology.

Original languageEnglish (US)
Title of host publicationImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI
DOIs
StatePublished - May 27 2013
EventImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI - San Francisco, CA, United States
Duration: Feb 2 2013Feb 5 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8587
ISSN (Print)1605-7422

Other

OtherImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI
CountryUnited States
CitySan Francisco, CA
Period2/2/132/5/13

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Liu, H., Qin, W., Shao, Y., Wang, Z., Yang, H., Runyan, R. B., Borg, T. K., & Gao, B. Z. (2013). Disassembly of myofibrils in adult cardiomyocytes during dedifferentiation. In Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI [85871W] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8587). https://doi.org/10.1117/12.2005156