Abstract
The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated pathophysiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective ligands. Here, we report the design, synthesis, biological activity, conformational analysis, and docking with receptors of two potent and selective agonists at the human MC3 receptor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 9773-9778 |
| Number of pages | 6 |
| Journal | Journal of Medicinal Chemistry |
| Volume | 58 |
| Issue number | 24 |
| DOIs | |
| State | Published - Dec 24 2015 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
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Carotenuto, A., Merlino, F., Cai, M., Brancaccio, D., Yousif, A. M., Novellino, E., Hruby, V. J., & Grieco, P. (2015). Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. Journal of Medicinal Chemistry, 58(24), 9773-9778. https://doi.org/10.1021/acs.jmedchem.5b01285