Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from Structure-Activity Studies of (+)-Migrastatin

Jón T. Njardarson; Christoph Gaul; Dandan Shan; Xin Yun Huang; Samuel J. Danishefsky

doi:10.1021/ja039714a

Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from Structure-Activity Studies of (+)-Migrastatin

Jón T. Njardarson, Christoph Gaul, Dandan Shan, Xin Yun Huang, Samuel J. Danishefsky

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

Synthesis of highly active migrastatin-based tumor migration cell inhibitors has been accomplished. Our flexible and concise total synthesis of migrastatin has allowed us to explore otherwise inaccessible migrastatin-derived structural motifs. This effort has resulted in the discovery of analogues with tumor cell migration inhibitory activity 3 orders of magnitude higher than that of the natural product.

Original language	English (US)
Pages (from-to)	1038-1040
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	126
Issue number	4
DOIs	https://doi.org/10.1021/ja039714a
State	Published - Feb 4 2004
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja039714a

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Discovery of Potent Cell Migration Inhibitors through Total Synthesis : Lessons from Structure-Activity Studies of (+)-Migrastatin. / Njardarson, Jón T.; Gaul, Christoph; Shan, Dandan; Huang, Xin Yun; Danishefsky, Samuel J.

In: Journal of the American Chemical Society, Vol. 126, No. 4, 04.02.2004, p. 1038-1040.

Research output: Contribution to journal › Article › peer-review

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