Abstract
Synthesis of highly active migrastatin-based tumor migration cell inhibitors has been accomplished. Our flexible and concise total synthesis of migrastatin has allowed us to explore otherwise inaccessible migrastatin-derived structural motifs. This effort has resulted in the discovery of analogues with tumor cell migration inhibitory activity 3 orders of magnitude higher than that of the natural product.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1038-1040 |
| Number of pages | 3 |
| Journal | Journal of the American Chemical Society |
| Volume | 126 |
| Issue number | 4 |
| DOIs | |
| State | Published - Feb 4 2004 |
| Externally published | Yes |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry
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Cite this
Njardarson, J. T., Gaul, C., Shan, D., Huang, X. Y., & Danishefsky, S. J. (2004). Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from Structure-Activity Studies of (+)-Migrastatin. Journal of the American Chemical Society, 126(4), 1038-1040. https://doi.org/10.1021/ja039714a