Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from Structure-Activity Studies of (+)-Migrastatin

Jón T. Njardarson, Christoph Gaul, Dandan Shan, Xin Yun Huang, Samuel J. Danishefsky

Research output: Contribution to journalArticle

157 Scopus citations

Abstract

Synthesis of highly active migrastatin-based tumor migration cell inhibitors has been accomplished. Our flexible and concise total synthesis of migrastatin has allowed us to explore otherwise inaccessible migrastatin-derived structural motifs. This effort has resulted in the discovery of analogues with tumor cell migration inhibitory activity 3 orders of magnitude higher than that of the natural product.

Original languageEnglish (US)
Pages (from-to)1038-1040
Number of pages3
JournalJournal of the American Chemical Society
Volume126
Issue number4
DOIs
StatePublished - Feb 4 2004
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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