Abstract
Synthesis of highly active migrastatin-based tumor migration cell inhibitors has been accomplished. Our flexible and concise total synthesis of migrastatin has allowed us to explore otherwise inaccessible migrastatin-derived structural motifs. This effort has resulted in the discovery of analogues with tumor cell migration inhibitory activity 3 orders of magnitude higher than that of the natural product.
Original language | English (US) |
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Pages (from-to) | 1038-1040 |
Number of pages | 3 |
Journal | Journal of the American Chemical Society |
Volume | 126 |
Issue number | 4 |
DOIs | |
State | Published - Feb 4 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry