Disease-related Myotubularins Function in Endocytic Traffic in Caenorhabditis elegans

Hope Dang, Zhai Li, Edward Y. Skolnik, Hanna Fares

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

MTM1, MTMR2, and SBF2 belong to a family of proteins called the myotubularins. X-linked myotubular myopathy, a severe congenital disorder characterized by hypotonia and generalized muscle weakness in newborn males, is caused by mutations in MTM1 (Laporte et al., 1996). Charcot-Marie-Tooth types 4B1 and 4B2 are severe demyelinating neuropathies caused by mutations in MTMR2 (Bolino et al., 2000) and SBF2/MTMR13 (Senderek et al., 2003), respectively. Although several myotubularins are known to regulate phosphoinositide-phosphate levels in cells, little is known about the actual cellular process that is defective in patients with these diseases. Mutations in worm MTM-6 and MTM-9, myotubularins belonging to two subgroups, disorganize phosphoinositide 3-phosphate localization and block endocytosis in the coelomocytes of Caenorhabditis elegans. We demonstrate that MTM-6 and MTM-9 function as part of a complex to regulate an endocytic pathway that involves the Arf6 GTPase, and we define protein domains required for MTM-6 activity.

Original languageEnglish (US)
Pages (from-to)189-196
Number of pages8
JournalMolecular biology of the cell
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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