Disease severity and family history in keratoconus

L. Szczotka-Flynn, M. Slaughter, T. McMahon, J. Barr, T. Edrington, B. Fink, J. Lass, Michael W Belin, S. K. Iyengar

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background/aims: To determine if disease severity is associated with a family history of keratoconus. Methods: Markers of disease severity in the CLEK Study cohort were assessed to determine if they could discriminate individuals with and without family history. Logistic regression was used to examine association between corneal scarring, average corneal power, flat and steep keratometry readings, and higher-order root mean square (RMS) wavefront error with family history. Results: In univariate analyses, none of the severity indices had any significant associations with family history; however, contact lens use, gender, and Caucasian race were found to be significant predictors. After controlling for these confounders, there were no significant associations between any severity indices and family history. Conclusions: Presence or absence of family history is not associated with more severe clinical disease, at least when each marker for severity is considered independently. The results of this analysis are important for genetic studies of keratoconus in that it will allow recruitment of keratoconus patients across all stages of disease severity because it does not influence familial aggregation.

Original languageEnglish (US)
Pages (from-to)1108-1111
Number of pages4
JournalBritish Journal of Ophthalmology
Volume92
Issue number8
DOIs
StatePublished - Aug 2008
Externally publishedYes

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Keratoconus
Contact Lenses
Patient Selection
Cicatrix
Reading
Cohort Studies
Logistic Models

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Szczotka-Flynn, L., Slaughter, M., McMahon, T., Barr, J., Edrington, T., Fink, B., ... Iyengar, S. K. (2008). Disease severity and family history in keratoconus. British Journal of Ophthalmology, 92(8), 1108-1111. https://doi.org/10.1136/bjo.2007.130294

Disease severity and family history in keratoconus. / Szczotka-Flynn, L.; Slaughter, M.; McMahon, T.; Barr, J.; Edrington, T.; Fink, B.; Lass, J.; Belin, Michael W; Iyengar, S. K.

In: British Journal of Ophthalmology, Vol. 92, No. 8, 08.2008, p. 1108-1111.

Research output: Contribution to journalArticle

Szczotka-Flynn, L, Slaughter, M, McMahon, T, Barr, J, Edrington, T, Fink, B, Lass, J, Belin, MW & Iyengar, SK 2008, 'Disease severity and family history in keratoconus', British Journal of Ophthalmology, vol. 92, no. 8, pp. 1108-1111. https://doi.org/10.1136/bjo.2007.130294
Szczotka-Flynn L, Slaughter M, McMahon T, Barr J, Edrington T, Fink B et al. Disease severity and family history in keratoconus. British Journal of Ophthalmology. 2008 Aug;92(8):1108-1111. https://doi.org/10.1136/bjo.2007.130294
Szczotka-Flynn, L. ; Slaughter, M. ; McMahon, T. ; Barr, J. ; Edrington, T. ; Fink, B. ; Lass, J. ; Belin, Michael W ; Iyengar, S. K. / Disease severity and family history in keratoconus. In: British Journal of Ophthalmology. 2008 ; Vol. 92, No. 8. pp. 1108-1111.
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