Abstract
Following the intravenous infusion of sodium diethyldithiocarbamate to dogs, the disposition kinetics of diethyldithiocarbamate (DDC), a metabolite of disulfiram, were assessed. Approximately 27% of the administered dose was S-methylated, this process exhibiting a mean first-order rate constant of 0. 0569 min-1 (t1/2=12.2 min), while the remainder was eliminated by other routes having a rate constant of 0.148 min-1 (t1/2=4.68 min). The methyl diethyldithiocarbamate (MeDDC) formed from DDC showed an elimination rate constant of 0.0141 min-1 (t1/2=49.2 min). These observations are discussed in the light of previous investigations where the presence of MeDDC has rarely been sought or reported. A few comparisons with prior studies, in which DDC or disulfiram was administered, are made by retrospective kinetic evaluation of published data. The results are discussed in relation to the duration of action of disulfiram in man.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 369-387 |
| Number of pages | 19 |
| Journal | Journal of Pharmacokinetics and Biopharmaceutics |
| Volume | 6 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1978 |
| Externally published | Yes |
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Keywords
- diethyldithiocarbamate metabolite of disulfiram
- dog
- kinetic evaluation of prior studies
- pharmacokinetics
- presence of methyl ester
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology (medical)
Cite this
Disposition kinetics in dogs of diethyldithiocarbamate, a metabolite of disulfiram. / Cobby, John; Mayersohn, Michael; Selliah, Sathi.
In: Journal of Pharmacokinetics and Biopharmaceutics, Vol. 6, No. 5, 10.1978, p. 369-387.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Disposition kinetics in dogs of diethyldithiocarbamate, a metabolite of disulfiram
AU - Cobby, John
AU - Mayersohn, Michael
AU - Selliah, Sathi
PY - 1978/10
Y1 - 1978/10
N2 - Following the intravenous infusion of sodium diethyldithiocarbamate to dogs, the disposition kinetics of diethyldithiocarbamate (DDC), a metabolite of disulfiram, were assessed. Approximately 27% of the administered dose was S-methylated, this process exhibiting a mean first-order rate constant of 0. 0569 min-1 (t1/2=12.2 min), while the remainder was eliminated by other routes having a rate constant of 0.148 min-1 (t1/2=4.68 min). The methyl diethyldithiocarbamate (MeDDC) formed from DDC showed an elimination rate constant of 0.0141 min-1 (t1/2=49.2 min). These observations are discussed in the light of previous investigations where the presence of MeDDC has rarely been sought or reported. A few comparisons with prior studies, in which DDC or disulfiram was administered, are made by retrospective kinetic evaluation of published data. The results are discussed in relation to the duration of action of disulfiram in man.
AB - Following the intravenous infusion of sodium diethyldithiocarbamate to dogs, the disposition kinetics of diethyldithiocarbamate (DDC), a metabolite of disulfiram, were assessed. Approximately 27% of the administered dose was S-methylated, this process exhibiting a mean first-order rate constant of 0. 0569 min-1 (t1/2=12.2 min), while the remainder was eliminated by other routes having a rate constant of 0.148 min-1 (t1/2=4.68 min). The methyl diethyldithiocarbamate (MeDDC) formed from DDC showed an elimination rate constant of 0.0141 min-1 (t1/2=49.2 min). These observations are discussed in the light of previous investigations where the presence of MeDDC has rarely been sought or reported. A few comparisons with prior studies, in which DDC or disulfiram was administered, are made by retrospective kinetic evaluation of published data. The results are discussed in relation to the duration of action of disulfiram in man.
KW - diethyldithiocarbamate metabolite of disulfiram
KW - dog
KW - kinetic evaluation of prior studies
KW - pharmacokinetics
KW - presence of methyl ester
UR - http://www.scopus.com/inward/record.url?scp=0018219382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018219382&partnerID=8YFLogxK
U2 - 10.1007/BF01062720
DO - 10.1007/BF01062720
M3 - Article
VL - 6
SP - 369
EP - 387
JO - Journal of Pharmacokinetics and Pharmacodynamics
JF - Journal of Pharmacokinetics and Pharmacodynamics
SN - 1567-567X
IS - 5
ER -