Disposition kinetics in dogs of diethyldithiocarbamate, a metabolite of disulfiram

John Cobby, Michael Mayersohn, Sathi Selliah

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Following the intravenous infusion of sodium diethyldithiocarbamate to dogs, the disposition kinetics of diethyldithiocarbamate (DDC), a metabolite of disulfiram, were assessed. Approximately 27% of the administered dose was S-methylated, this process exhibiting a mean first-order rate constant of 0. 0569 min-1 (t1/2=12.2 min), while the remainder was eliminated by other routes having a rate constant of 0.148 min-1 (t1/2=4.68 min). The methyl diethyldithiocarbamate (MeDDC) formed from DDC showed an elimination rate constant of 0.0141 min-1 (t1/2=49.2 min). These observations are discussed in the light of previous investigations where the presence of MeDDC has rarely been sought or reported. A few comparisons with prior studies, in which DDC or disulfiram was administered, are made by retrospective kinetic evaluation of published data. The results are discussed in relation to the duration of action of disulfiram in man.

Original languageEnglish (US)
Pages (from-to)369-387
Number of pages19
JournalJournal of Pharmacokinetics and Biopharmaceutics
Volume6
Issue number5
DOIs
StatePublished - Oct 1 1978

Keywords

  • diethyldithiocarbamate metabolite of disulfiram
  • dog
  • kinetic evaluation of prior studies
  • pharmacokinetics
  • presence of methyl ester

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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