Disposition kinetics of cefamandole during continuous ambulatory peritoneal dialysis

M. Bliss, Michael Mayersohn, T. Arnold, J. Logan, U. F. Michael, W. Jones

Research output: Contribution to journalArticle

Abstract

Cefamandole disposition kinetics were examined in six male subjects with renal impairment who were undergoing continuous ambulatory peritoneal dialysis. Creatinine clearance values ranged from <1 to 11 ml/min. Cefamandole was given as a 1-g intravenous dose infused over 30 min. Cefamandole concentrations were determined in serum, urine, and dialysis fluid by a high-performance liquid chromatographic method. The following average parameter values were obtained (range): half-life, 6.1 h (4.6 to 9.7); systemic clearance, 21.9 ml/min (8.4 to 35.5); renal clearance, 11.5 ml/min (0.03 to 22.3); dailysis clearance, 0.92 ml/min (0.7 to 1.3); nonrenal clearance, 12.2 ml/min (2.9 to 27.0); volume of distribution, 0.18 liter/kg (0.09 to 0.25); steady-state volume of distribution, 0.17 liter/kg (0.09 to 0.24). Approximately 5% of the dose was dialyzed (range, 2.8 to 8.3), indicating that there is no need to supplement a dosing regimen of cefamandole due to loss by dailysis. There was a positive correlation between creatinine clearance and the terminal elimination rate constant of cefamandole (r2 = 0.41) and cefamandole renal clearance (r2 = 0.83).

Original languageEnglish (US)
Pages (from-to)649-653
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume29
Issue number4
StatePublished - 1986

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Cefamandole
Continuous Ambulatory Peritoneal Dialysis
Kidney
Creatinine
Half-Life
Dialysis
Urine
Serum

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Disposition kinetics of cefamandole during continuous ambulatory peritoneal dialysis. / Bliss, M.; Mayersohn, Michael; Arnold, T.; Logan, J.; Michael, U. F.; Jones, W.

In: Antimicrobial Agents and Chemotherapy, Vol. 29, No. 4, 1986, p. 649-653.

Research output: Contribution to journalArticle

Bliss, M, Mayersohn, M, Arnold, T, Logan, J, Michael, UF & Jones, W 1986, 'Disposition kinetics of cefamandole during continuous ambulatory peritoneal dialysis', Antimicrobial Agents and Chemotherapy, vol. 29, no. 4, pp. 649-653.
Bliss, M. ; Mayersohn, Michael ; Arnold, T. ; Logan, J. ; Michael, U. F. ; Jones, W. / Disposition kinetics of cefamandole during continuous ambulatory peritoneal dialysis. In: Antimicrobial Agents and Chemotherapy. 1986 ; Vol. 29, No. 4. pp. 649-653.
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AU - Jones, W.

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