Disposition kinetics of two oral forms of quinidine

W. A. Mahon, M. Mayersohn, T. Inaba

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

There are relatively few studies on the disposition properties of quinidine. We have studied in 10 normal subjects conventional quinidine sulfate and a slow-release quinidine bisulfate. Single and repetitive doses were given; blood and urine concentrations were measured by the method of Cramer and Isaakson.5 After a single dose of two tablets of quinidine sulfate (400 mg), the average peak concentration was 2.13 ± 0.22 μg/ml (±SEM); following two tablets of the slow-release form, the average peak concentration was 1.17 ± 0.12 μg/ml T-max was approximately 2 hr with quinidine sulfate and 4 hr with quinidine bisulfate. One fourth of both forms of the drug was recovered in the urine. Total body clearance was 0.36 Llkg ·hr and renal clearance was 117 ± 22 ml/min for both. With multiple dosing the serum quinidine concentration was higher than these predicted from the results of the single-dose study. Based on the mean estimates of quinidine half-life of 6 hr, a rapid method for achieving steady-state levels of quinidine would be to give an initial dose twice that of the maintenance dose. With the slow-release product if an equivalent dose was given every 12 hr, the mean steady-state quinidine serum concentration would be approximately the same.

Original languageEnglish (US)
Pages (from-to)566-575
Number of pages10
JournalClinical Pharmacology and Therapeutics
Volume19
Issue number5 PART 1
DOIs
StatePublished - May 1976

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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