Dissociation of analgesic and gastrointestinal effects of electroconvulsive shock-released opioids

James J. Galligan, Frank Porreca, Thomas F. Burks

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Activation of endogenous opioid systems by electroconvulsive shock (ECS) produced naloxone-reversible thermal analgesia (52 °C hot plate) 5 min after ECS administration. Although pioid peptides injected intracerebroventricularly have previously been found to inhibit gastrointestinal motility, ECS treatment did not affect gastric emptying, small or large intestinal transit. These results suggest that centrally-mediated opioid analgesia and changes in gastrointestinal motility are initiated through independent mechanisms.

Original languageEnglish (US)
Pages (from-to)354-357
Number of pages4
JournalBrain Research
Volume271
Issue number2
DOIs
StatePublished - Jul 25 1983

Keywords

  • electroconvulsive shock
  • endogenous opioids
  • gastrointestinal motility
  • thermal analgesia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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