Distinct expression patterns for two Xenopus Bar homeobox genes

Kristin D. Patterson, Ondine Cleaver, Wendy V. Gerber, Frank G. White, Paul A Krieg

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The BarH1 and BarH2 homeobox genes are coexpressed in cells of the fly retina and in the central and peripheral nervous systems. The fly Bar genes are required for normal development of the eye and external sensory organs. In Xenopus we have identified two distinct vertebrate Bar-related homeobox genes, XBH1 and XBH2. XBH1 is highly related in sequence and expression pattern to a mammalian gene, MBH1, suggesting that they are orthologues. XBH2 has not previously been identified but is clearly related to the Drosophila Bar genes. During early Xenopus embryogenesis XBH1 and XBH2 are expressed in overlapping regions of the central nervous system. XBH1, but not XBH2, is expressed in the developing retina. By comparing the expression of XBH1 with that of hermes, a marker of differentiated retinal ganglion cells, we show that XBH1 is expressed in retinal ganglion cells during the differentiation process, but is down-regulated as cells become terminally differentiated.

Original languageEnglish (US)
Pages (from-to)140-144
Number of pages5
JournalDevelopment Genes and Evolution
Volume210
Issue number3
StatePublished - 2000

Fingerprint

homeotic genes
Homeobox Genes
Xenopus
Retinal Ganglion Cells
retina
Diptera
central nervous system
Retina
gene
Central Nervous System
Genes
nervous system
peripheral nervous system
genes
sense organs
Peripheral Nervous System
cells
cell differentiation
Drosophila
Embryonic Development

Keywords

  • Bar homeodomain protein
  • Eye development
  • Gene expression

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology
  • Genetics
  • Ecology, Evolution, Behavior and Systematics

Cite this

Patterson, K. D., Cleaver, O., Gerber, W. V., White, F. G., & Krieg, P. A. (2000). Distinct expression patterns for two Xenopus Bar homeobox genes. Development Genes and Evolution, 210(3), 140-144.

Distinct expression patterns for two Xenopus Bar homeobox genes. / Patterson, Kristin D.; Cleaver, Ondine; Gerber, Wendy V.; White, Frank G.; Krieg, Paul A.

In: Development Genes and Evolution, Vol. 210, No. 3, 2000, p. 140-144.

Research output: Contribution to journalArticle

Patterson, KD, Cleaver, O, Gerber, WV, White, FG & Krieg, PA 2000, 'Distinct expression patterns for two Xenopus Bar homeobox genes', Development Genes and Evolution, vol. 210, no. 3, pp. 140-144.
Patterson KD, Cleaver O, Gerber WV, White FG, Krieg PA. Distinct expression patterns for two Xenopus Bar homeobox genes. Development Genes and Evolution. 2000;210(3):140-144.
Patterson, Kristin D. ; Cleaver, Ondine ; Gerber, Wendy V. ; White, Frank G. ; Krieg, Paul A. / Distinct expression patterns for two Xenopus Bar homeobox genes. In: Development Genes and Evolution. 2000 ; Vol. 210, No. 3. pp. 140-144.
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