Distribution of binding sites for 125I labeled α bungarotoxin in normal and deafferented antennal lobes of Manduca sexta

J. G. Hildebrand, L. M. Hall, B. C. Osmond

Research output: Contribution to journalArticle

107 Scopus citations

Abstract

125I-Labeled α-bungarotoxin has been used to determine the distribution of putative acetylcholine receptors in normal and chronically deafferented antennal lobes in the brain of the moth Manduca sexta. Toxin-binding sites are confined to synaptic regions in the neuropil of normal lobes and to rudiments of these regions in deafferented lobes. These findings suggest that receptors can develop in the insect central nervous system independently of normal synaptic influences.

Original languageEnglish (US)
Pages (from-to)499-503
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number1
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

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