Distribution of technetium-99m-labeled multilamellar liposomes in patients with Hodgkin's disease

R. Perez-Soler, G. Lopez-Berestein, L. P. Kasi, F. Cabanillas, M. Jahns, H. Glenn, Evan M Hersh, T. Haynie

Research output: Contribution to journalArticle

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Abstract

The distribution of 99mTc-labeled multilamellar liposomes composed of dimyristoyl phosphatidylcholine (DMPC) and dimyristoyl phosphatidylglycerol (DMPG) at a molar ratio of 7:3, administered intravenously, was studied in 10 patients with Hodgkin's disease (HD). The dose of lipid was 150 mg/m2 and the mean dose of radioactivity injected per patient was 8.1 mCi (range 6.7-9.8). Whole-body imaging techniques were used, and for each organ an uptake index was calculated as the percent photographic density (PD) relative to the PD of the liver. Results were compared to those in a group of 6 patients with other malignancies. Increased liposome uptake in several skeletal areas was observed in one patient with HD with diffuse bone involvement and in the bone marrow of 2 patients with HD with bone marrow involvement. No definite liposome uptake was observed in lymph nodes involved by HD or in tumor areas of patients with other malignancies. Patients with HD had a significantly higher uptake by bone marrow (23.8% compared with 10.2% at 4 hr, p = 0.02), and lungs (59.6% compared with 25.0% at 4 hr, p = 0.01) than patients with other malignancies. Among patients with HD, the uptake by bone marrow and lungs were higher in those with constitutional symptoms (bone marrow at 4 hr 31.4% compared with 16.2%, p = 0.02; lungs at 4 hr 68.8% compared with 50.4%, p = 0.19) and with liver involvement (bone marrow at 4 hr 30.8% compared with 16.8%, p = 0.03; lungs at 4 hr 73.6% compared with 45.6%, p = 0.03). These results suggest that patients with HD have a different pattern of distribution of multilamellar liposomes which may be related to a combination of nonspecific stimulation of the reticuloendothelial system and tumor uptake. It does not appear that liposomal 99mTc is capable of adequately imaging HD for clinical diagnosis.

Original languageEnglish (US)
Pages (from-to)743-749
Number of pages7
JournalJournal of Nuclear Medicine
Volume26
Issue number7
StatePublished - 1985
Externally publishedYes

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Technetium
Hodgkin Disease
Liposomes
Bone Marrow
Lung
Neoplasms
Whole Body Imaging
Mononuclear Phagocyte System
Specific Gravity
Liver
Phosphatidylcholines
Radioactivity
Lymph Nodes
Lipids
Bone and Bones

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Perez-Soler, R., Lopez-Berestein, G., Kasi, L. P., Cabanillas, F., Jahns, M., Glenn, H., ... Haynie, T. (1985). Distribution of technetium-99m-labeled multilamellar liposomes in patients with Hodgkin's disease. Journal of Nuclear Medicine, 26(7), 743-749.

Distribution of technetium-99m-labeled multilamellar liposomes in patients with Hodgkin's disease. / Perez-Soler, R.; Lopez-Berestein, G.; Kasi, L. P.; Cabanillas, F.; Jahns, M.; Glenn, H.; Hersh, Evan M; Haynie, T.

In: Journal of Nuclear Medicine, Vol. 26, No. 7, 1985, p. 743-749.

Research output: Contribution to journalArticle

Perez-Soler, R, Lopez-Berestein, G, Kasi, LP, Cabanillas, F, Jahns, M, Glenn, H, Hersh, EM & Haynie, T 1985, 'Distribution of technetium-99m-labeled multilamellar liposomes in patients with Hodgkin's disease', Journal of Nuclear Medicine, vol. 26, no. 7, pp. 743-749.
Perez-Soler R, Lopez-Berestein G, Kasi LP, Cabanillas F, Jahns M, Glenn H et al. Distribution of technetium-99m-labeled multilamellar liposomes in patients with Hodgkin's disease. Journal of Nuclear Medicine. 1985;26(7):743-749.
Perez-Soler, R. ; Lopez-Berestein, G. ; Kasi, L. P. ; Cabanillas, F. ; Jahns, M. ; Glenn, H. ; Hersh, Evan M ; Haynie, T. / Distribution of technetium-99m-labeled multilamellar liposomes in patients with Hodgkin's disease. In: Journal of Nuclear Medicine. 1985 ; Vol. 26, No. 7. pp. 743-749.
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abstract = "The distribution of 99mTc-labeled multilamellar liposomes composed of dimyristoyl phosphatidylcholine (DMPC) and dimyristoyl phosphatidylglycerol (DMPG) at a molar ratio of 7:3, administered intravenously, was studied in 10 patients with Hodgkin's disease (HD). The dose of lipid was 150 mg/m2 and the mean dose of radioactivity injected per patient was 8.1 mCi (range 6.7-9.8). Whole-body imaging techniques were used, and for each organ an uptake index was calculated as the percent photographic density (PD) relative to the PD of the liver. Results were compared to those in a group of 6 patients with other malignancies. Increased liposome uptake in several skeletal areas was observed in one patient with HD with diffuse bone involvement and in the bone marrow of 2 patients with HD with bone marrow involvement. No definite liposome uptake was observed in lymph nodes involved by HD or in tumor areas of patients with other malignancies. Patients with HD had a significantly higher uptake by bone marrow (23.8{\%} compared with 10.2{\%} at 4 hr, p = 0.02), and lungs (59.6{\%} compared with 25.0{\%} at 4 hr, p = 0.01) than patients with other malignancies. Among patients with HD, the uptake by bone marrow and lungs were higher in those with constitutional symptoms (bone marrow at 4 hr 31.4{\%} compared with 16.2{\%}, p = 0.02; lungs at 4 hr 68.8{\%} compared with 50.4{\%}, p = 0.19) and with liver involvement (bone marrow at 4 hr 30.8{\%} compared with 16.8{\%}, p = 0.03; lungs at 4 hr 73.6{\%} compared with 45.6{\%}, p = 0.03). These results suggest that patients with HD have a different pattern of distribution of multilamellar liposomes which may be related to a combination of nonspecific stimulation of the reticuloendothelial system and tumor uptake. It does not appear that liposomal 99mTc is capable of adequately imaging HD for clinical diagnosis.",
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