Distribution of the microelastic properties within the human anterior mitral leaflet

Anne Skakkebæk Jensen, Ulrik Baandrup, J. Michael Hasenkam, Tribikram Kundu, Claus Schiøtt Jørgensen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Knowledge of the biomechanical properties of the mitral valve leaflets and their relation to histologic structure is of importance for understanding the leaflet movement characteristics under normal and pathologic conditions, but such knowledge is not yet available. The aim of this study was to determine biomechanical properties of the human anterior mitral leaflet on a microscopic scale. We used scanning acoustic microscopy (SAM) to examine the human anterior mitral leaflet. Sections of fixed human anterior mitral leaflet tissue were obtained from postmortem human anterior mitral leaflets (n = 5). We measured the speed of sound (νL) in each histologic layer in three regions-of-interest (ROIs): these were at the annular edge, at the valve midpoint and close to the free edge. νL varied in the three histologic layers (p < 0.01). It was higher in the fibrous layer (1.76 km/s) compared with the atrial layer (1.75 km/s) and ventricular layer (1.73 km/s). Also, νL differed between positions along the length of the annulus-free edge line (p < 0.01), showing a decline from the annular edge (1.76 km/s) to the free edge (1.73 km/s), both as a whole and also within the atrial and the fibrous layer. These results demonstrate that the fibrous layer is stiffer than the atrial and ventricular layer and that the leaflet as a whole and within the atrial and the fibrous layer is stiffer at the annulus part in comparison with those near the free edge. (E-mail: asj@ki.au.dk).

Original languageEnglish (US)
Pages (from-to)1943-1948
Number of pages6
JournalUltrasound in Medicine and Biology
Volume32
Issue number12
DOIs
StatePublished - Dec 2006

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Acoustic Microscopy
Mitral Valve
annuli
acoustics
microscopy
scanning

Keywords

  • Biomechanics
  • Elastic properties
  • Mitral valve
  • Scanning acoustic microscopy
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Distribution of the microelastic properties within the human anterior mitral leaflet. / Jensen, Anne Skakkebæk; Baandrup, Ulrik; Hasenkam, J. Michael; Kundu, Tribikram; Jørgensen, Claus Schiøtt.

In: Ultrasound in Medicine and Biology, Vol. 32, No. 12, 12.2006, p. 1943-1948.

Research output: Contribution to journalArticle

Jensen, Anne Skakkebæk ; Baandrup, Ulrik ; Hasenkam, J. Michael ; Kundu, Tribikram ; Jørgensen, Claus Schiøtt. / Distribution of the microelastic properties within the human anterior mitral leaflet. In: Ultrasound in Medicine and Biology. 2006 ; Vol. 32, No. 12. pp. 1943-1948.
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