Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation

Tsuhen M. Chang, Elisa Tomat

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A disulfide bond is incorporated in the scaffold of thiosemicarbazone iron chelators as a reduction/activation switch. Following reduction, thiol-containing ligands stabilize iron ions in their trivalent oxidation state. The antiproliferative activity of the new chelating systems is assessed in human cancer cell lines and in normal tissue.

Original languageEnglish (US)
Pages (from-to)7846-7849
Number of pages4
JournalDalton Transactions
Volume42
Issue number22
DOIs
StatePublished - Jun 14 2013

Fingerprint

Thiosemicarbazones
Chelation
Sulfhydryl Compounds
Disulfides
Iron
Switches
Ligands
Chelating Agents
Scaffolds
Thermodynamic properties
Chemical activation
Cells
Ions
Tissue
Oxidation
Oxidation-Reduction

ASJC Scopus subject areas

  • Inorganic Chemistry

Cite this

Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation. / Chang, Tsuhen M.; Tomat, Elisa.

In: Dalton Transactions, Vol. 42, No. 22, 14.06.2013, p. 7846-7849.

Research output: Contribution to journalArticle

@article{e48754e7d8154c9db70cb22ec8e5bd7d,
title = "Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation",
abstract = "A disulfide bond is incorporated in the scaffold of thiosemicarbazone iron chelators as a reduction/activation switch. Following reduction, thiol-containing ligands stabilize iron ions in their trivalent oxidation state. The antiproliferative activity of the new chelating systems is assessed in human cancer cell lines and in normal tissue.",
author = "Chang, {Tsuhen M.} and Elisa Tomat",
year = "2013",
month = "6",
day = "14",
doi = "10.1039/c3dt50824b",
language = "English (US)",
volume = "42",
pages = "7846--7849",
journal = "Dalton Transactions",
issn = "1477-9226",
publisher = "Royal Society of Chemistry",
number = "22",

}

TY - JOUR

T1 - Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation

AU - Chang, Tsuhen M.

AU - Tomat, Elisa

PY - 2013/6/14

Y1 - 2013/6/14

N2 - A disulfide bond is incorporated in the scaffold of thiosemicarbazone iron chelators as a reduction/activation switch. Following reduction, thiol-containing ligands stabilize iron ions in their trivalent oxidation state. The antiproliferative activity of the new chelating systems is assessed in human cancer cell lines and in normal tissue.

AB - A disulfide bond is incorporated in the scaffold of thiosemicarbazone iron chelators as a reduction/activation switch. Following reduction, thiol-containing ligands stabilize iron ions in their trivalent oxidation state. The antiproliferative activity of the new chelating systems is assessed in human cancer cell lines and in normal tissue.

UR - http://www.scopus.com/inward/record.url?scp=84878038782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878038782&partnerID=8YFLogxK

U2 - 10.1039/c3dt50824b

DO - 10.1039/c3dt50824b

M3 - Article

C2 - 23591852

AN - SCOPUS:84878038782

VL - 42

SP - 7846

EP - 7849

JO - Dalton Transactions

JF - Dalton Transactions

SN - 1477-9226

IS - 22

ER -