Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation

Tsuhen M. Chang, Elisa Tomat

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A disulfide bond is incorporated in the scaffold of thiosemicarbazone iron chelators as a reduction/activation switch. Following reduction, thiol-containing ligands stabilize iron ions in their trivalent oxidation state. The antiproliferative activity of the new chelating systems is assessed in human cancer cell lines and in normal tissue.

Original languageEnglish (US)
Pages (from-to)7846-7849
Number of pages4
JournalDalton Transactions
Volume42
Issue number22
DOIs
StatePublished - Jun 14 2013

ASJC Scopus subject areas

  • Inorganic Chemistry

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