Diuresis with continuous infusion of furosemide after cardiac surgery

Jack G. Copeland, David W. Campbell, John R. Plachetka, Neal W. Salomon, Douglas F Larson

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

We prospectively evaluated the diuretic effect of furosemide administered by bolus injection and by continuous infusion in 18 cardiac surgery patients. Nine patients were randomly assigned to receive 0.3 mg/kg of furosemide as a bolus injection at time 0 and again 6 hours later (nine patients) or 0.05 mg/kg per hour of furosemide as a constant infusion for 12 hours (nine patients). There were no significant differences between groups with respect to age, weight, creatinine clearance, changes in serum sodium and potassium levels, total urinary concentrations of sodium and potassium, or total urine volume for 12 hours. Diuresis during continuous infusion of furosemide was less variable from hour to hour than after bolus injection of furosemide and was sustained throughout the infusion period. Although the continuous infusion of furosemide will not provide the rapid and vigorous diuresis that is necessary in some clinical situations, it may be useful whenever a gentle, sustained diuresis is desired.

Original languageEnglish (US)
Pages (from-to)796-799
Number of pages4
JournalAmerican Journal of Surgery
Volume146
Issue number6
DOIs
StatePublished - 1983
Externally publishedYes

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Diuresis
Furosemide
Thoracic Surgery
Injections
Potassium
Sodium
Diuretics
Creatinine
Urine
Weights and Measures
Serum

ASJC Scopus subject areas

  • Surgery

Cite this

Diuresis with continuous infusion of furosemide after cardiac surgery. / Copeland, Jack G.; Campbell, David W.; Plachetka, John R.; Salomon, Neal W.; Larson, Douglas F.

In: American Journal of Surgery, Vol. 146, No. 6, 1983, p. 796-799.

Research output: Contribution to journalArticle

Copeland, Jack G. ; Campbell, David W. ; Plachetka, John R. ; Salomon, Neal W. ; Larson, Douglas F. / Diuresis with continuous infusion of furosemide after cardiac surgery. In: American Journal of Surgery. 1983 ; Vol. 146, No. 6. pp. 796-799.
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