Diversity-Oriented Combinatorial Biosynthesis of Hybrid Polyketide Scaffolds from Azaphilone and Benzenediol Lactone Biosynthons

Jing Bai, Yuanyuan Lu, Ya Ming Xu, Wei Zhang, Ming Chen, Min Lin, Leslie Gunatilaka, Yuquan Xu, Istvan Molnar

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Two disparate polyketide families, the benzenediol lactones and the azaphilones, are produced by fungi using iterative polyketide synthase (iPKS) enzymes consisting of collaborating partner subunits. Exploitation of this common biosynthetic logic using iPKS subunit shuffling allowed the diversity-oriented combinatorial biosynthesis of unprecedented polyketide scaffolds new to nature, bearing structural motifs from both of these orthogonal natural product families. Starter unit acyltransferase domain replacements proved necessary but not sufficient to guarantee communication between iPKS subunits.

Original languageEnglish (US)
Pages (from-to)1262-1265
Number of pages4
JournalOrganic Letters
Volume18
Issue number6
DOIs
StatePublished - Mar 18 2016

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ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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