DNA acting like RNA

Robert V. Brown, Laurence Hurley

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Over the last decade or so, secondary non-B-DNA structures such as G-quadruplexes and i-motifs have come into focus as biologically functioning moieties that are potentially involved in telomeric interactions and the control of gene expression. In the present short review, we first describe the structural and dynamic parallels with complex RNA structures, including the importance of sequence and ions in folding, and then we describe the biological consequences of the folded structures. We conclude that there are considerable parallels between secondary and tertiary structures in RNA and DNA from both the folding and the biological perspectives.

Original languageEnglish (US)
Pages (from-to)635-640
Number of pages6
JournalBiochemical Society Transactions
Volume39
Issue number2
DOIs
StatePublished - Apr 2011

Fingerprint

RNA
G-Quadruplexes
DNA
Gene expression
Ions
Gene Expression
DNA-like RNA

Keywords

  • G-quadruplex
  • i-motif
  • RNA
  • Secondary DNA structure

ASJC Scopus subject areas

  • Biochemistry

Cite this

DNA acting like RNA. / Brown, Robert V.; Hurley, Laurence.

In: Biochemical Society Transactions, Vol. 39, No. 2, 04.2011, p. 635-640.

Research output: Contribution to journalArticle

Brown, Robert V. ; Hurley, Laurence. / DNA acting like RNA. In: Biochemical Society Transactions. 2011 ; Vol. 39, No. 2. pp. 635-640.
@article{c833dc492a4041f19a7e5bbf97f43dcb,
title = "DNA acting like RNA",
abstract = "Over the last decade or so, secondary non-B-DNA structures such as G-quadruplexes and i-motifs have come into focus as biologically functioning moieties that are potentially involved in telomeric interactions and the control of gene expression. In the present short review, we first describe the structural and dynamic parallels with complex RNA structures, including the importance of sequence and ions in folding, and then we describe the biological consequences of the folded structures. We conclude that there are considerable parallels between secondary and tertiary structures in RNA and DNA from both the folding and the biological perspectives.",
keywords = "G-quadruplex, i-motif, RNA, Secondary DNA structure",
author = "Brown, {Robert V.} and Laurence Hurley",
year = "2011",
month = "4",
doi = "10.1042/BST0390635",
language = "English (US)",
volume = "39",
pages = "635--640",
journal = "Biochemical Society Transactions",
issn = "0300-5127",
publisher = "Portland Press Ltd.",
number = "2",

}

TY - JOUR

T1 - DNA acting like RNA

AU - Brown, Robert V.

AU - Hurley, Laurence

PY - 2011/4

Y1 - 2011/4

N2 - Over the last decade or so, secondary non-B-DNA structures such as G-quadruplexes and i-motifs have come into focus as biologically functioning moieties that are potentially involved in telomeric interactions and the control of gene expression. In the present short review, we first describe the structural and dynamic parallels with complex RNA structures, including the importance of sequence and ions in folding, and then we describe the biological consequences of the folded structures. We conclude that there are considerable parallels between secondary and tertiary structures in RNA and DNA from both the folding and the biological perspectives.

AB - Over the last decade or so, secondary non-B-DNA structures such as G-quadruplexes and i-motifs have come into focus as biologically functioning moieties that are potentially involved in telomeric interactions and the control of gene expression. In the present short review, we first describe the structural and dynamic parallels with complex RNA structures, including the importance of sequence and ions in folding, and then we describe the biological consequences of the folded structures. We conclude that there are considerable parallels between secondary and tertiary structures in RNA and DNA from both the folding and the biological perspectives.

KW - G-quadruplex

KW - i-motif

KW - RNA

KW - Secondary DNA structure

UR - http://www.scopus.com/inward/record.url?scp=79953214116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953214116&partnerID=8YFLogxK

U2 - 10.1042/BST0390635

DO - 10.1042/BST0390635

M3 - Article

C2 - 21428953

AN - SCOPUS:79953214116

VL - 39

SP - 635

EP - 640

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 2

ER -