DNA biomarkers in aging skin

Kimberly G. Norman, Alex Eshaghian, James E Sligh

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Aging of the skin is the result of both the intrinsic chronological aging process and extrinsic damage caused by environmental factors. A major role of the skin is that of protection from external environmental factors. Ultraviolet radiation (UVR) is the most significant environmental insult to the skin. UVR comprises the spectrum of electromagnetic radiation between the wavelengths of 200 and 400 nm. UVR is subdivided into three categories, each of which has distinct biological effects: UVA (320-400 nm), UVB (280-320 nm), and UVC (200-280 nm). The stratospheric ozone blocks the radiation whose wavelength is below 290 nm, effectively preventing the entire UVC spectrum and part of the UVB spectrum from reaching human skin. The UVR that does reach the human skin can cause molecular defects including DNA damage, lipid peroxidation, and protein cross-linking, which can lead to premature skin aging or photoaging. Photoaging is a term used to describe the clinical and histological features of chronically UV-exposed skin [1].

Original languageEnglish (US)
Title of host publicationTextbook of Aging Skin
PublisherSpringer Berlin Heidelberg
Pages453-457
Number of pages5
ISBN (Print)9783540896555
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Skin Aging
Biomarkers
Radiation
Skin
DNA
Stratospheric Ozone
Premature Aging
Electromagnetic Radiation
Conservation of Natural Resources
Lipid Peroxidation
DNA Damage
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Norman, K. G., Eshaghian, A., & Sligh, J. E. (2010). DNA biomarkers in aging skin. In Textbook of Aging Skin (pp. 453-457). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-89656-2_47

DNA biomarkers in aging skin. / Norman, Kimberly G.; Eshaghian, Alex; Sligh, James E.

Textbook of Aging Skin. Springer Berlin Heidelberg, 2010. p. 453-457.

Research output: Chapter in Book/Report/Conference proceedingChapter

Norman, KG, Eshaghian, A & Sligh, JE 2010, DNA biomarkers in aging skin. in Textbook of Aging Skin. Springer Berlin Heidelberg, pp. 453-457. https://doi.org/10.1007/978-3-540-89656-2_47
Norman KG, Eshaghian A, Sligh JE. DNA biomarkers in aging skin. In Textbook of Aging Skin. Springer Berlin Heidelberg. 2010. p. 453-457 https://doi.org/10.1007/978-3-540-89656-2_47
Norman, Kimberly G. ; Eshaghian, Alex ; Sligh, James E. / DNA biomarkers in aging skin. Textbook of Aging Skin. Springer Berlin Heidelberg, 2010. pp. 453-457
@inbook{6c3fd7b2e2c645c79fd17685aac25b58,
title = "DNA biomarkers in aging skin",
abstract = "Aging of the skin is the result of both the intrinsic chronological aging process and extrinsic damage caused by environmental factors. A major role of the skin is that of protection from external environmental factors. Ultraviolet radiation (UVR) is the most significant environmental insult to the skin. UVR comprises the spectrum of electromagnetic radiation between the wavelengths of 200 and 400 nm. UVR is subdivided into three categories, each of which has distinct biological effects: UVA (320-400 nm), UVB (280-320 nm), and UVC (200-280 nm). The stratospheric ozone blocks the radiation whose wavelength is below 290 nm, effectively preventing the entire UVC spectrum and part of the UVB spectrum from reaching human skin. The UVR that does reach the human skin can cause molecular defects including DNA damage, lipid peroxidation, and protein cross-linking, which can lead to premature skin aging or photoaging. Photoaging is a term used to describe the clinical and histological features of chronically UV-exposed skin [1].",
author = "Norman, {Kimberly G.} and Alex Eshaghian and Sligh, {James E}",
year = "2010",
doi = "10.1007/978-3-540-89656-2_47",
language = "English (US)",
isbn = "9783540896555",
pages = "453--457",
booktitle = "Textbook of Aging Skin",
publisher = "Springer Berlin Heidelberg",

}

TY - CHAP

T1 - DNA biomarkers in aging skin

AU - Norman, Kimberly G.

AU - Eshaghian, Alex

AU - Sligh, James E

PY - 2010

Y1 - 2010

N2 - Aging of the skin is the result of both the intrinsic chronological aging process and extrinsic damage caused by environmental factors. A major role of the skin is that of protection from external environmental factors. Ultraviolet radiation (UVR) is the most significant environmental insult to the skin. UVR comprises the spectrum of electromagnetic radiation between the wavelengths of 200 and 400 nm. UVR is subdivided into three categories, each of which has distinct biological effects: UVA (320-400 nm), UVB (280-320 nm), and UVC (200-280 nm). The stratospheric ozone blocks the radiation whose wavelength is below 290 nm, effectively preventing the entire UVC spectrum and part of the UVB spectrum from reaching human skin. The UVR that does reach the human skin can cause molecular defects including DNA damage, lipid peroxidation, and protein cross-linking, which can lead to premature skin aging or photoaging. Photoaging is a term used to describe the clinical and histological features of chronically UV-exposed skin [1].

AB - Aging of the skin is the result of both the intrinsic chronological aging process and extrinsic damage caused by environmental factors. A major role of the skin is that of protection from external environmental factors. Ultraviolet radiation (UVR) is the most significant environmental insult to the skin. UVR comprises the spectrum of electromagnetic radiation between the wavelengths of 200 and 400 nm. UVR is subdivided into three categories, each of which has distinct biological effects: UVA (320-400 nm), UVB (280-320 nm), and UVC (200-280 nm). The stratospheric ozone blocks the radiation whose wavelength is below 290 nm, effectively preventing the entire UVC spectrum and part of the UVB spectrum from reaching human skin. The UVR that does reach the human skin can cause molecular defects including DNA damage, lipid peroxidation, and protein cross-linking, which can lead to premature skin aging or photoaging. Photoaging is a term used to describe the clinical and histological features of chronically UV-exposed skin [1].

UR - http://www.scopus.com/inward/record.url?scp=84892131089&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892131089&partnerID=8YFLogxK

U2 - 10.1007/978-3-540-89656-2_47

DO - 10.1007/978-3-540-89656-2_47

M3 - Chapter

AN - SCOPUS:84892131089

SN - 9783540896555

SP - 453

EP - 457

BT - Textbook of Aging Skin

PB - Springer Berlin Heidelberg

ER -